P H Pekala
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Explore the profile of P H Pekala including associated specialties, affiliations and a list of published articles.
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52
Citations
914
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Recent Articles
1.
Qi C, Karkut C, Lombardi N, Pruett A, Tenney R, Wheeler J, et al.
Adv Enzyme Regul
. 2001 Jun;
41:209-20.
PMID: 11384746
No abstract available.
2.
Qi C, Pekala P
Proc Soc Exp Biol Med
. 2000 Feb;
223(2):128-35.
PMID: 10654615
Recent studies examining the link between insulin resistance and the development of obesity and noninsulin-dependent diabetes mellitus are consistent with the involvement of tumor necrosis factor-alpha (TNF-alpha) as a central...
3.
Qi C, Pekala P
Biochem Biophys Res Commun
. 1999 Sep;
263(2):265-9.
PMID: 10491282
One mechanism for modification of glucose transport activity occurs through regulation of the cellular content of transporter protein by alteration of transcript stability. Regulated mRNA decay has been shown to...
4.
Jain R, Phelps K, Pekala P
J Cell Physiol
. 1999 Mar;
179(1):58-66.
PMID: 10082133
Examination of the ability of tumor necrosis factor-alpha (TNF) to activate both the p44/42 and p38 MAP kinase cascades in fully differentiated 3T3-L1 adipocytes indicated a rapid MEK1/2-dependent activation of...
5.
Jain R, Police S, Phelps K, Pekala P
Biochem J
. 1999 Mar;
338 ( Pt 3):737-43.
PMID: 10051447
We have demonstrated previously that treatment of 3T3-L1 adipocytes with tumour necrosis factor-alpha (TNF) results in a rapid (4 h) and significant (75-80%) reduction in the rate of transcription of...
6.
Jain R, Meredith M, Pekala P
Adv Enzyme Regul
. 1998 Oct;
38:333-47.
PMID: 9762361
We have previously demonstrated that exposure of fully differentiated 3T3-L1 adipocytes to TNF results in an activation of at least two separate signal transduction pathways: 1. the sphingomyelinase leading to...
7.
Stewart W, Pekala P, Lieberman E
Glia
. 1998 Jul;
23(4):349-60.
PMID: 9671965
Na+/K+-ATPase-dependent Rb+ uptake of RN22 Schwann cells was stimulated by cholera toxin (0.25 microg/ml), forskolin (2 mM), or 8-bromo cAMP (1 mM). At 2 h Rb+ uptake was increased by...
8.
Jain R, Andrews L, McGowan K, Pekala P, Keene J
Mol Cell Biol
. 1997 Feb;
17(2):954-62.
PMID: 9001249
3T3-L1 preadipocytes ectopically expressing the mammalian RNA-binding protein Hel-N1 expressed up to 10-fold more glucose transporter (GLUT1) protein and exhibited elevated rates of basal glucose uptake. Hel-N1 is a member...
9.
McGowan K, Police S, WINSLOW J, Pekala P
J Biol Chem
. 1997 Jan;
272(2):1331-7.
PMID: 8995440
In the current study we report on the contribution of the GLUT1 3'-untranslated region (UTR) to the stability of the GLUT1 mRNA. To facilitate these investigations, a hybrid construct was...
10.
Long S, Pekala P
Biochem J
. 1996 Oct;
319 ( Pt 1):179-84.
PMID: 8870666
We have previously demonstrated that chronic exposure of 3T3-L1 adipocytes to tumour necrosis factor-alpha (TNF) resulted in a marked decrease (approximately 90%) in cellular GLUT4 (insulin-responsive glucose transporter) mRNA content...