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J L Grem

Explore the profile of J L Grem including associated specialties, affiliations and a list of published articles. Areas
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Articles 114
Citations 1032
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Recent Articles
1.
Belongia E, Costa J, Gareen I, Grem J, Inadomi J, Kern E, et al.
NIH Consens State Sci Statements . 2008 Oct; 25(2):1-29. PMID: 18949020
Objective: To provide health care providers, patients, and the general public with a responsible assessment of currently available data on the management of hepatitis B. Participants: A non-DHHS, nonadvocate 12-member...
2.
Lehky T, Leonard G, Wilson R, Grem J, Floeter M
Muscle Nerve . 2004 Feb; 29(3):387-92. PMID: 14981738
Oxaliplatin, a platinum-based chemotherapeutic agent, is effective in the treatment of solid tumors, particularly colorectal cancer. During and immediately following oxaliplatin infusion, patients may experience cold-induced paresthesias, throat and jaw...
3.
Wright M, Schuler B, Szabo E, Grem J
Ann Oncol . 2003 Mar; 14(4):659-60. PMID: 12649120
No abstract available.
4.
Grem J, Yee L, Schuler B, HAMILTON J, Chen A, Chabuk C, et al.
Ann Oncol . 2002 Feb; 12(11):1581-7. PMID: 11822758
Background: We have reported that N-(phosphonacetyl)-L-aspartic acid (PALA) 1266 mg/m2 can safely be given 24 hours prior to the start of a 72-hour infusion of fluorouracil (FUra) and leucovorin (LV)...
5.
Ismail A, Grem J
Cancer Chemother Biol Response Modif . 2001 Nov; 19:1-19. PMID: 11686010
No abstract available.
6.
Thomas R, Dahut W, Harold N, Grem J, Monahan B, Liang M, et al.
Cancer Chemother Pharmacol . 2001 Oct; 48(3):215-22. PMID: 11592343
Purpose: To define the toxicity profile and the recommended phase II doses of 9-aminocamptothecin (9-AC) administered as a weekly 120-h infusion. Methods: 9-AC was administered over 120 h weekly to...
7.
Saif M, Wilson R, Harold N, Keith B, Dougherty D, Grem J
Anticancer Drugs . 2001 Jul; 12(6):525-31. PMID: 11459999
5-Fluorouracil (5-FU)-associated neurotoxicity is uncommon; symptoms may occur abruptly or more gradually during the course of chemotherapy. Peripheral neuropathy with 5-FU therapy has only rarely been reported. Two patients treated...
8.
Agnew E, Wilson R, Grem J, Neckers L, Bi D, Takimoto C
J Chromatogr B Biomed Sci Appl . 2001 Jun; 755(1-2):237-43. PMID: 11393709
A sensitive HPLC assay has been developed to determine the concentration of 17-(allylamino)-17-demethoxygeldanamycin (AAG) in human plasma over the concentration range of 12.5 to 2,500 nM (7.33 to 1,465 ng/mL)....
9.
Guemei A, Cottrell J, Band R, Hehman H, Prudhomme M, Pavlov M, et al.
Cancer Chemother Pharmacol . 2001 May; 47(4):283-90. PMID: 11345644
Purpose: To characterize the relationships between human plasma irinotecan carboxylesterase-converting enzyme activity, caboxylesterase-mediated hydrolysis of p-nitrophenyl acetate (pNPA), and the butyrylcholinesterase-mediated hydrolysis of butyrylthiocholine in human plasma and to test...
10.
Grem J, Danenberg K, Behan K, Parr A, Young L, Danenberg P, et al.
Clin Cancer Res . 2001 Apr; 7(4):999-1009. PMID: 11309351
Purpose: To determine the expression of three targets of 5-fluorouracil (5-FU) and 5-fluoro-2'-deoxyuridine (FdUrd) in human tumor cell lines and to compare these with the 50% growth inhibition concentrations (GI(50))...