P G De Benedetti
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Explore the profile of P G De Benedetti including associated specialties, affiliations and a list of published articles.
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47
Citations
303
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Recent Articles
1.
De Rienzo F, Gabdoulline R, Menziani M, De Benedetti P, Wade R
Biophys J
. 2001 Nov;
81(6):3090-104.
PMID: 11720977
The oxidation of cytochrome f by the soluble cupredoxin plastocyanin is a central reaction in the photosynthetic electron transfer chain of all oxygenic organisms. Here, two different computational approaches are...
2.
Barlocco D, Cignarella G, Piaz V, Giovannoni M, De Benedetti P, Fanelli F, et al.
J Med Chem
. 2001 Jul;
44(15):2403-10.
PMID: 11448222
QSAR models have been used for designing a series of compounds characterized by a N-phenylpiperazinylalkylamino moiety linked to substituted pyridazinones, which have been synthesized. Measurements of the binding affinities of...
3.
Cotecchia S, Rossier O, Fanelli F, Leonardi A, De Benedetti P
Pharm Acta Helv
. 2000 May;
74(2-3):173-9.
PMID: 10812955
In this chapter we summarize some aspects of the structure-functional relationship of the alpha 1a and alpha 1b-adrenergic receptor subtypes related to the receptor activation process as well as the...
4.
De Rienzo F, Fanelli F, Menziani M, De Benedetti P
J Comput Aided Mol Des
. 2000 Mar;
14(1):93-116.
PMID: 10702928
Three-dimensional models of the cytochromes P450 IA2, P450 IID6 and P450 IIIA4 were built by means of comparative modeling using the X-ray crystallographic structures of P450 CAM, P450 BM-3, P450...
5.
Scheer A, Costa T, Fanelli F, De Benedetti P, Mhaouty-Kodja S, Abuin L, et al.
Mol Pharmacol
. 2000 Jan;
57(2):219-31.
PMID: 10648631
We have suggested previously that both the negatively and positively charged residues of the highly conserved Glu/Asp-Arg-Tyr (E/DRY) motif play an important role in the activation process of the alpha(1b)-adreneric...
6.
Menziani M, Montorsi M, De Benedetti P, Karelson M
Bioorg Med Chem
. 2000 Jan;
7(11):2437-51.
PMID: 10632053
A quantitative structure-activity relationship (QSAR) study of a wide series of structurally diverse alpha1-adrenergic receptor antagonists was performed using the CODESSA (Comprehensive Descriptors for Structural and Statistical Analysis) technique. Theoretical...
7.
Fanelli F, Menziani C, Scheer A, Cotecchia S, De Benedetti P
Proteins
. 1999 Dec;
37(2):145-56.
PMID: 10584061
This study proposes a theoretical model describing the electrostatically driven step of the alpha 1 b-adrenergic receptor (AR)-G protein recognition. The comparative analysis of the structural-dynamics features of functionally different...
8.
Scheer A, Fanelli F, Diviani D, De Benedetti P, Cotecchia S
Eur Urol
. 1999 Jul;
36 Suppl 1:11-6.
PMID: 10393467
The alpha1b-adrenergic receptor (AR) is a member of the large superfamily of seven transmembrane domain (TMD) G protein-coupled receptors (GPCR). Combining site-directed mutagenesis of the alpha1b-AR with computational simulations of...
9.
Fanelli F, Barbier P, Zanchetta D, De Benedetti P, Chini B
Mol Pharmacol
. 1999 Jul;
56(1):214-25.
PMID: 10385703
The aim of this study was to investigate the molecular changes associated with the transition of the human oxytocin receptor from its inactive to its active states. Mutation of the...
10.
Cappelli A, Anzini M, Vomero S, Canullo L, Mennuni L, Makovec F, et al.
J Med Chem
. 1999 May;
42(9):1556-75.
PMID: 10229626
Novel 5-HT3 receptor ligands were designed and synthesized with the aim of obtaining deeper insight into the molecular basis of the intrinsic efficacy of arylpiperazines interacting with the central 5-HT3...