P F Torrence
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Explore the profile of P F Torrence including associated specialties, affiliations and a list of published articles.
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151
Citations
881
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Recent Articles
1.
Player M, Torrence P
Curr Protoc Nucleic Acid Chem
. 2008 Apr;
Chapter 4:Unit 4.4.
PMID: 18428851
This unit provides protocols for the synthesis and characterization of 2-5A-antisense nucleic acids. These chimeric oligonucleotides consist of 2',5'-phosphodiester-linked oligoadenylates ligated to 3',5'-deoxyribonucleotides and are readily prepared using phosphoramidite chemistry...
2.
Torrence P
Drug News Perspect
. 2003 Aug;
13(4):226-33.
PMID: 12937627
Respiratory syncytial virus (RSV) is the major cause of lower respiratory tract infection in infants and young children, and is also a significant threat to other populations including the immunosuppressed,...
3.
Torrence P
Curr Opin Mol Ther
. 2001 Nov;
1(3):307-15.
PMID: 11713795
A new approach to the chemical control of respiratory syncytial virus infection is reviewed in the context of the biology of the virus and previous treatment approaches. Conjugation of the...
4.
5.
Adah S, Bayly S, Cramer H, Silverman R, Torrence P
Curr Med Chem
. 2001 Jul;
8(10):1189-212.
PMID: 11472236
This review describes the application of a natural defense mechanism to develop effective agents for the post-transcriptional control of gene expression. 2-5A is a unique 2',5'-phosphodiester bond linked oligoadenylate, (pp)p5'A2'(p5'A)(n),...
6.
Verheijen J, Chen L, Bayly S, Torrence P, van der Marel G, VAN Boom J
Nucleosides Nucleotides Nucleic Acids
. 2001 Feb;
19(10-12):1821-30.
PMID: 11200276
Fully automated solid-phase synthesis gave access to a hybrid in which 5'-phosphorylated-2'-5'-linked oligoadenylate (2-5A) is connected to the 5'-terminus of DNA which, in turn, is linked at the 3'-end to...
7.
Wang Z, Chen L, Bayly S, Torrence P
Bioorg Med Chem Lett
. 2000 Jul;
10(12):1357-60.
PMID: 10890163
2-5A was conjugated to N-(2-aminoethyl)-glycyl PNA by periodate oxidization, followed by coupling with amino-derivatized PNA and final cyanoborohydride reduction. An adduct of 2-5A pentamer with tetrameric thymine PNA activated RNase...
8.
Verheijen J, van Roon A, Meeuwenoord N, Stuivenberg H, Bayly S, Chen L, et al.
Bioorg Med Chem Lett
. 2000 Apr;
10(8):801-4.
PMID: 10782690
Incorporation of a 4-hydroxy-N-acetylprolinol nucleotide analogue at the 3'-terminus of DNA or 2-5A-DNA sequences resulted in a significantly enhanced 3'-exonuclease resistance while the affinity for complementary RNA was only slightly...
9.
Geselowitz D, Cramer H, Wondrak E, Player M, Torrence P
Antisense Nucleic Acid Drug Dev
. 2000 Mar;
10(1):45-51.
PMID: 10726660
A method is described for monitoring the cleavage of an oligoribonucleotide substrate by the 2-5A-dependent RNase L based on fluorescence resonance energy transfer (FRET). The oligoribonucleotide, rC11U2C7, was labeled covalently...
10.
Kitade Y, Wakana M, Tsuboi T, Yatome C, Bayly S, Player M, et al.
Bioorg Med Chem Lett
. 2000 Mar;
10(4):329-31.
PMID: 10714492
2-Methyladenosine-substituted analogues of 2-5A, p5'A2'p5'A2'p5'(me2A), p5'(me2A)2'p5'A2'p5'A, and p5'(me2A) 2'p5'(me2A)2'pS'(me2A), were prepared via a modification of a lead ion-catalyzed ligation reaction. These 5'-monophosphates were subsequently converted into the corresponding 5'-triphosphates. Both...