P F Davies
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Explore the profile of P F Davies including associated specialties, affiliations and a list of published articles.
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81
Citations
3022
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Recent Articles
1.
Davies P, Shi C, Depaola N, Helmke B, Polacek D
Ann N Y Acad Sci
. 2002 Jan;
947:7-16; discussion 16-7.
PMID: 11795312
Atherosclerosis originates at predictable focal and regional sites that are associated with complex flow disturbances and flow separations in large arteries. The spatial relationships associated with hemodynamic shear stress forces...
2.
Helmke B, Thakker D, Goldman R, Davies P
Biophys J
. 2001 Feb;
80(1):184-94.
PMID: 11159394
The distribution of hemodynamic shear stress throughout the arterial tree is transduced by the endothelium into local cellular responses that regulate vasoactivity, vessel wall remodeling, and atherogenesis. Although the exact...
3.
Levitan I, Helmke B, Davies P
Ann Biomed Eng
. 2001 Jan;
28(10):1184-93.
PMID: 11144979
An obstacle to real-time in vitro measurements of endothelial cell responses to hemodynamic forces is the inaccessibility of the cells to instruments of measurement and manipulation. We have designed a...
4.
Helmke B, Goldman R, Davies P
Circ Res
. 2000 Apr;
86(7):745-52.
PMID: 10764407
Hemodynamic shear stress at the endothelial cell surface induces acute and chronic intracellular responses that regulate vessel wall biology. The cytoskeleton is implicated by acting both as a direct connector...
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Barakat A, Leaver E, Pappone P, Davies P
Circ Res
. 1999 Oct;
85(9):820-8.
PMID: 10532950
Shear stress-induced activation of endothelial ion channels, one of the earliest responses to flow, is implicated in mechano-signal transduction that results in the regulation of vascular tone. The effects of...
7.
Davies P, Polacek D, Handen J, Helmke B, Depaola N
Trends Biotechnol
. 1999 Aug;
17(9):347-51.
PMID: 10461179
The initiation and progression of focal atherosclerotic lesions has long been known to be associated with regions of disturbed blood flow. Improved precision in experimental models of spatially defined flow...
8.
Depaola N, Davies P, Pritchard Jr W, Florez L, Harbeck N, Polacek D
Proc Natl Acad Sci U S A
. 1999 Mar;
96(6):3154-9.
PMID: 10077653
Hemodynamic regulation of the endothelial gap junction protein connexin43 (Cx43) was studied in a model of controlled disturbed flows in vitro. Cx43 mRNA, protein expression, and intercellular communication were mapped...
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