P E Keeting
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Explore the profile of P E Keeting including associated specialties, affiliations and a list of published articles.
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20
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197
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Recent Articles
1.
Secreto F, Grover A, Pacurari M, Rice M, Kantorow M, Bidwai A, et al.
Calcif Tissue Int
. 2003 Sep;
73(6):565-74.
PMID: 12958688
Reports that estrogen treatment modulates arachidonic acid metabolism by bone and bone cells are found in the literature. However, conflicting indications of the relationship that exists between estrogen and arachidonic...
2.
Keeting P, Li C, Murty M, Xu J, Cissel D, Whipkey D, et al.
J Cell Biochem
. 1998 Sep;
71(1):74-81.
PMID: 9736456
The eicosanoids, including prostaglandin E2 (PGE2) and other bioactive arachidonic acid metabolites, are important local mediators of bone remodeling. Presumably, the limited or excessive synthesis of the eicosanoids could compromise...
3.
Keeting P, Li C, Whipkey D, Thweatt R, Xu J, Murty M, et al.
J Cell Biochem
. 1998 Jan;
68(2):237-46.
PMID: 9443079
The steroid derivative 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) is a regulator of bone biology, and there is evidence that 1,25(OH)2D3 modulates arachidonic acid metabolism in osteoblastic cell model systems and in bone...
4.
Xu J, Cissel D, Varghese S, Whipkey D, Blaha J, Graeber G, et al.
J Cell Biochem
. 1997 Mar;
64(4):618-31.
PMID: 9093911
Prostaglandin (PG) biosynthesis by cytokine stimulated normal adult human osteoblast-like (hOB) cells was evaluated by thin layer chromatography, high performance liquid chromatography, and specific immunoassays. PGE2 was the predominant PG...
5.
Cissel D, Murty M, Whipkey D, Blaha J, Graeber G, Keeting P
J Cell Biochem
. 1996 Feb;
60(2):260-70.
PMID: 8655636
Eicosanoids are multifunctional autocrine/paracrine regulators of bone that are enzymatically derived from arachidonic acid (AA). The rate-limiting step in the eicosanoid biosynthetic pathways may be the release of AA from...
6.
Pivirotto L, Cissel D, Keeting P
Mol Cell Endocrinol
. 1995 Apr;
111(1):67-74.
PMID: 7649354
The mechanisms by which the sex hormones achieve their bone-sparing effects remains unresolved. Interleukin-1 beta (IL-1 beta) is an autocrine/paracrine regulator of bone that may be produced in an estrogen-sensitive...
7.
Cissel D, Birkle D, Whipkey D, Blaha J, Graeber G, Keeting P
J Cell Biochem
. 1995 Apr;
57(4):599-609.
PMID: 7615644
The effects of treatment with the osteotropic steroids 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), 17 beta-estradiol, or dexamethasone on [1-14C]arachidonic acid (AA) uptake and distribution into glycerophospholipid classes by normal adult human osteoblast-like...
8.
Subramaniam M, Colvard D, Keeting P, Rasmussen K, Riggs B, Spelsberg T
J Cell Biochem
. 1992 Dec;
50(4):411-24.
PMID: 1469072
In humans, glucocorticoids are known to have marked effects on bone metabolism and function, including the significant regulation of osteoblast cells. To aid in the understanding of the mechanism of...
9.
Keeting P, Oursler M, Wiegand K, Bonde S, Spelsberg T, Riggs B
J Bone Miner Res
. 1992 Nov;
7(11):1281-9.
PMID: 1334616
Silicon in trace amounts enhances bone formation, and the silicon-containing compound zeolite A (ZA) increases eggshell thickness in hens. In the studies reported here, treatment of nearly homogeneous strains of...
10.
Keeting P, Scott R, Colvard D, Anderson M, Oursler M, Spelsberg T, et al.
J Bone Miner Res
. 1992 Feb;
7(2):127-36.
PMID: 1373929
A new bone cell line was established by transfecting normal adult human osteoblast-like (hOB) cells, derived from a 68-year-old woman, with the plasmid pSV3 neo. The plasmid included coding sequences...