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P E James

Explore the profile of P E James including associated specialties, affiliations and a list of published articles. Areas
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Articles 40
Citations 420
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Recent Articles
1.
Nash J, Davies A, Saunders C, George C, Williams J, James P
Transfus Med . 2023 Aug; 33(6):467-477. PMID: 37553476
Background: Platelet derived extracellular vesicles (EVs) display a pro-coagulant phenotype and are generated throughout platelet concentrate (PC) storage. Cold storage (CS) of PCs is thought to provide a superior haemostatic...
2.
Williams J, Nash J, Whelan C, Raven B, Davies A, Evans J, et al.
Thromb Res . 2022 Jul; 217:76-85. PMID: 35908384
The coronavirus, COVID-19 pandemic spread across the globe in 2020, with an initial high case mortality in those requiring intensive care treatment due to serious complication. A vaccine programme was...
3.
Anderson R, Bundhoo S, James P
Atherosclerosis . 2014 Dec; 237(1):369-73. PMID: 25443875
This article outlines a new hypothesis that illustrates the potential role of the stomach (and subsequent chemical reactions involving nitrite therein) in modifying thienopyridines, such as clopidogrel. Gastric modification of...
4.
Willis G, Connolly K, Ladell K, Davies T, Guschina I, Ramji D, et al.
Hum Reprod . 2014 Oct; 29(12):2756-63. PMID: 25336711
Study Question: Are circulating microparticles (MPs) altered in young women with polycystic ovary syndrome (PCOS)? Summary Answer: Women with PCOS have elevated concentrations of circulating platelet-derived MPs, which exhibit increased...
5.
Willis G, Udiawar M, Evans W, Blundell H, James P, Rees D
BJOG . 2014 May; 121(13):1596-603. PMID: 24816317
Objective: To assess circulating biochemical indices of endothelial function and nitro-oxidative stress in women with polycystic ovary syndrome (PCOS). Design: Case-control study. Population: Seventeen women with PCOS and eighteen age-...
6.
Yakeu G, Butcher L, Isa S, Webb R, Roberts A, Thomas A, et al.
Atherosclerosis . 2010 Aug; 212(2):668-73. PMID: 20723894
Objective: Pharmacological activation of the nuclear receptor PPARγ is linked to numerous beneficial effects in the contexts of inflammation, lipid homeostasis, Type-2 Diabetes (T2D) and atherosclerosis. These beneficial effects include...
7.
Pinder A, Pittaway E, Morris K, James P
Br J Pharmacol . 2009 Jul; 157(8):1523-30. PMID: 19594749
Background And Purpose: It is postulated that nitrite requires reduction to nitric oxide in order to exert its relaxant effect upon isolated hypoxic vessels. Herein, we evaluate the relative contribution...
8.
Bailey D, Evans K, James P, McEneny J, Young I, Fall L, et al.
J Physiol . 2008 Oct; 587(1):73-85. PMID: 18936082
We tested the hypothesis that dynamic cerebral autoregulation (CA) and blood-brain barrier (BBB) function would be compromised in acute mountain sickness (AMS) subsequent to a hypoxia-mediated alteration in systemic free...
9.
Paton J, Lonergan T, Deuchars J, James P, Kasparov S
Auton Neurosci . 2006 Apr; 126-127:193-201. PMID: 16580888
We previously identified an action of nitric oxide (NO) within the nucleus tractus solitarii (NTS) that attenuates the cardiac component of the baroreceptor reflex. In the present study we have...
10.
Milsom A, Jones C, Goodfellow J, Frenneaux M, Peters J, James P
Diabetologia . 2002 Nov; 45(11):1515-22. PMID: 12436334
Aims/hypothesis: Reduced bioavailability of endothelium-derived nitric oxide is implicated in diabetic macrovascular and microvascular disease. In patients with diabetes, we hypothesised that protein glycosylation can alter nitric oxide binding affinity...