P Darrell Neufer
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Explore the profile of P Darrell Neufer including associated specialties, affiliations and a list of published articles.
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101
Citations
5012
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Recent Articles
1.
Jevtovic F, Zheng D, Claiborne A, Biagioni E, Wisseman B, Krassovskaia P, et al.
Physiol Rep
. 2024 Apr;
12(9):e16028.
PMID: 38684442
Maternal exercise (ME) has been established as a useful non-pharmacological intervention to improve infant metabolic health; however, mechanistic insight behind these adaptations remains mostly confined to animal models. Infant mesenchymal...
2.
Ryan T, Torres M, Lin C, Clark A, Brophy P, Smith C, et al.
JCI Insight
. 2024 Feb;
9(4).
PMID: 38385748
BACKGROUNDWhile the benefits of statin therapy on atherosclerotic cardiovascular disease are clear, patients often experience mild to moderate skeletal myopathic symptoms, the mechanism for which is unknown. This study investigated...
3.
Schmidt C, Hale B, Bhowmick D, Miller W, Neufer P, Geyer C
Dev Cell
. 2023 Dec;
59(1):79-90.e6.
PMID: 38101411
Sperm gain fertilization competence in the female reproductive tract through a series of biochemical changes and a requisite switch from linear progressive to hyperactive motility. Despite being essential for fertilization,...
4.
Pal A, Lin C, Boykov I, Benson E, Kidd G, Fisher-Wellman K, et al.
Nutrients
. 2023 Nov;
15(22).
PMID: 38004202
Diet-induced obesity impairs mitochondrial respiratory responses in tissues that are highly metabolically active, such as the heart. However, less is known about the impact of obesity on the respiratory activity...
5.
Scandalis L, Kitzman D, Nicklas B, Lyles M, Brubaker P, Nelson M, et al.
JAMA Cardiol
. 2023 May;
8(6):575-584.
PMID: 37163294
Importance: The pathophysiology of exercise intolerance in patients with heart failure with preserved ejection fraction (HFpEF) remains incompletely understood. Multiple lines of evidence suggest that abnormal skeletal muscle metabolism is...
6.
Fisher-Wellman K, Kassai M, Hagen J, Neufer P, Kester M, Loughran Jr T, et al.
Cancers (Basel)
. 2023 Mar;
15(6).
PMID: 36980769
Acute myelogenous leukemia (AML), the most prevalent acute and aggressive leukemia diagnosed in adults, often recurs as a difficult-to-treat, chemotherapy-resistant disease. Because chemotherapy resistance is a major obstacle to successful...
7.
Matthews C, Fussner L, Yaeger M, Aloor J, Reece S, Kilburg-Basnyat B, et al.
Prostaglandins Leukot Essent Fatty Acids
. 2023 Jan;
190:102540.
PMID: 36706677
Prohibitins (PHB1 and PHB2) are ubiquitously expressed proteins which play critical roles in multiple biological processes, and together form the ring-like PHB complex found in phospholipid-rich cellular compartments including lipid...
8.
Hagen J, Montgomery M, Biagioni E, Krassovskaia P, Jevtovic F, Shookster D, et al.
Biochim Biophys Acta Bioenerg
. 2022 Sep;
1863(8):148915.
PMID: 36058252
Although the development of chemoresistance is multifactorial, active chemotherapeutic efflux driven by upregulations in ATP binding cassette (ABC) transporters are commonplace. Chemotherapeutic efflux pumps, like ABCB1, couple drug efflux to...
9.
Tang Y, Zong H, Kwon H, Qiu Y, Pessin J, Wu L, et al.
Elife
. 2022 Mar;
11.
PMID: 35254259
Cholinergic and sympathetic counter-regulatory networks control numerous physiological functions, including learning/memory/cognition, stress responsiveness, blood pressure, heart rate, and energy balance. As neurons primarily utilize glucose as their primary metabolic energy...
10.
Pereyra A, Lin C, Mesa Sanchez D, Laskin J, Spangenburg E, Neufer P, et al.
Mol Metab
. 2022 Feb;
59:101456.
PMID: 35150906
Objective: Skeletal muscle is a heterogeneous and dynamic tissue that adapts to functional demands and substrate availability by modulating muscle fiber size and type. The concept of muscle fiber type...