Alpha 2.0
Login Register
» Authors » P DArpa

P DArpa

Explore the profile of P DArpa including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 18
Citations 489
Followers 0
Related Specialties
Oncology
Genetics
Biochemistry
Top 10 Co-Authors
L F Liu
J R Williams
D Jacobson-Kram
W C Earnshaw
D W Cleveland
N F Rothfield
M Anderson
C Beardmore
H Ratrie 3rd
P Duann
Published In
Cancer Res
Mutat Res
Cancer Cells
Proc Natl Acad Sci U S A
Basic Life Sci
Affiliations
Soon will be listed here.
Recent Articles
1.
Replication-dependent and -independent camptothecin cytotoxicity of seven human colon tumor cell lines
Borovitskaya A, DArpa P
Oncol Res . 1998 Nov; 10(5):271-6. PMID: 9802062
Anticancer inhibitors of topoisomerase I (TOP1, EC 5.99.1.2) cause the reversible stabilization of the TOP1-DNA covalent complex (cleavable complex). The cleavable complex can be converted into a double-strand break, the...
2.
The CHO XRCC1 mutant, EM9, deficient in DNA ligase III activity, exhibits hypersensitivity to camptothecin independent of DNA replication
Barrows L, Holden J, Anderson M, DArpa P
Mutat Res . 1998 Sep; 408(2):103-10. PMID: 9739812
We have analyzed the X-ray-sensitive CHO mutant cell line EM9 for sensitivity to the topoisomerase I inhibitor comptothecin. These cells exhibit defective repair of single strand DNA breaks. Recently, EM9...
3.
Ubiquitin-dependent destruction of topoisomerase I is stimulated by the antitumor drug camptothecin
Desai S, Liu L, DArpa P
J Biol Chem . 1997 Sep; 272(39):24159-64. PMID: 9305865
Topoisomerase I (TOP1) relaxes superhelical DNA through a breakage/rejoining reaction in which the active site tyrosine links covalently to a 3' phosphate at the break site as a transient intermediate....
4.
Mechanism of action of camptothecin
Liu L, Duann P, Lin C, DArpa P, Wu J
Ann N Y Acad Sci . 1996 Dec; 803:44-9. PMID: 8993499
No abstract available.
5.
Cell cycle-specific and transcription-related phosphorylation of mammalian topoisomerase I
DArpa P, Liu L
Exp Cell Res . 1995 Mar; 217(1):125-31. PMID: 7867711
Eukaryotic DNA topoisomerase I has been recently shown to be associated with the transcriptional machinery and has also been implicated to function in DNA replication and perhaps other DNA transactions....
6.
Determinants of cellular sensitivity to topoisomerase-targeting antitumor drugs
DArpa P
Adv Pharmacol . 1994 Jan; 29B:127-43. PMID: 8996605
It is now clear that topoisomerase activity level is an important determinant of sensitivity to topo drugs. The regulation of topoisomerases is no doubt complex and multifaceted and is probably...
7.
The involvement of active DNA synthesis in camptothecin-induced G2 arrest: altered regulation of p34cdc2/cyclin B
Tsao Y, DArpa P, Liu L
Cancer Res . 1992 Apr; 52(7):1823-9. PMID: 1312900
Cell cycle arrest in G2 phase is a common response to a variety of DNA-damaging agents. The coupling between DNA damage and G2 arrest was studied in synchronized HeLa cells...
8.
Topoisomerase-targeting antitumor drugs: mechanisms of cytotoxicity and resistance
Liu L, DArpa P
Important Adv Oncol . 1992 Jan; :79-89. PMID: 1316311
No abstract available.
9.
Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons
DArpa P, Beardmore C, Liu L
Cancer Res . 1990 Nov; 50(21):6919-24. PMID: 1698546
The primary cytotoxic mechanism of camptothecin has been proposed to involve an interaction between the replication machinery and the camptothecin-mediated topoisomerase I-DNA cleavable complex (Y. H. Hsiang, M.G. Lihou, and...
10.
Use of molecular cloning methods to map the distribution of epitopes on topoisomerase I (Scl-70) recognized by sera of scleroderma patients
DArpa P, White-Cooper H, Cleveland D, Rothfield N, Earnshaw W
Arthritis Rheum . 1990 Oct; 33(10):1501-11. PMID: 1699543
We report the initial molecular characterization of the autoimmune response against DNA topoisomerase I (topo I; Scl-70). Sera from 36 patients with scleroderma and 4 healthy control subjects were studied...