P D Jeffrey
Overview
Explore the profile of P D Jeffrey including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
87
Citations
3196
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
21.
Jeffrey P, Schildbach J, Chang C, Kussie P, Margolies M, Sheriff S
J Mol Biol
. 1995 Apr;
248(2):344-60.
PMID: 7739045
We determined the sequence, specificity for structurally related cardenolides, and three-dimensional structure of the anti-digoxin antibody 40-50 Fab in complex with ouabain. The 40-50 antibody does not share close sequence...
22.
Jeffrey P, Gorina S, Pavletich N
Science
. 1995 Mar;
267(5203):1498-502.
PMID: 7878469
The p53 protein is a tetrameric transcription factor that plays a central role in the prevention of neoplastic transformation. Oligomerization appears to be essential for the tumor suppressing activity of...
23.
Schildbach J, Milla M, Jeffrey P, Raumann B, Sauer R
Biochemistry
. 1995 Jan;
34(4):1405-12.
PMID: 7827088
Arc repressor is a small, dimeric DNA-binding protein that belongs to the ribbon-helix-helix family of transcription factors. Replacing Pro8 at the N-terminal end of the beta-sheet with leucine increases the...
24.
Chang C, Shih H, Jeffrey P, Margolies M, Sheriff S
Acta Crystallogr D Biol Crystallogr
. 1994 Nov;
50(Pt 6):915-7.
PMID: 15299362
The Fab fragments of several monoclonal antibodies that bind digoxin and other cardiac glycosides have been screened for crystallization conditions. We have crystallized two of these in forms suitable for...
25.
Cho Y, Gorina S, Jeffrey P, Pavletich N
Science
. 1994 Jul;
265(5170):346-55.
PMID: 8023157
Mutations in the p53 tumor suppressor are the most frequently observed genetic alterations in human cancer. The majority of the mutations occur in the core domain which contains the sequence-specific...
26.
Schildbach J, Shaw S, Bruccoleri R, Haber E, Herzenberg L, Jager G, et al.
Protein Sci
. 1994 May;
3(5):737-49.
PMID: 8061604
Two distinct spontaneous variants of the murine anti-digoxin hybridoma 26-10 were isolated by fluorescence-activated cell sorting for reduced affinity of surface antibody for antigen. Nucleotide and partial amino acid sequencing...
27.
Vasudevan S, Gedye C, Dixon N, Cheah E, Carr P, Suffolk P, et al.
FEBS Lett
. 1994 Jan;
337(3):255-8.
PMID: 8293810
The Escherichia coli signal transduction protein PII, product of the glnB gene, was overproduced and purified. The predicted molecular weight of the protein based on the correct nucleotide sequence is...
28.
Chang C, Jeffrey P, Bajorath J, Hellstrom I, Hellstrom K, Sheriff S
J Mol Biol
. 1994 Jan;
235(1):372-6.
PMID: 8289260
The monoclonal anti-tumor antibody BR96 binds a tetrasaccharide, Lewis y (Le(y)), in vitro and recognizes a Le(y)-bearing or Le(y)-related tumor-associated antigen in vivo. The Fab of the murine monoclonal antibody,...
29.
Jeffrey P, Strong R, Sieker L, Chang C, Campbell R, Petsko G, et al.
Proc Natl Acad Sci U S A
. 1993 Nov;
90(21):10310-4.
PMID: 8234291
We have determined the three-dimensional structures of the antigen-binding fragment of the anti-digoxin monoclonal antibody 26-10 in the uncomplexed state at 2.7 A resolution and as a complex with digoxin...
30.
Schildbach J, Near R, Bruccoleri R, Haber E, Jeffrey P, Ng S, et al.
J Biol Chem
. 1993 Oct;
268(29):21739-47.
PMID: 7691815
Antibody produced by a variant of the murine antidigoxin hybridoma 26-10 has reduced affinity for digoxin but enhanced recognition of the digoxin 12-hydroxyl due to a Tyr to His substitution...