P D Jeffrey
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Explore the profile of P D Jeffrey including associated specialties, affiliations and a list of published articles.
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87
Citations
3196
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Recent Articles
11.
Sheriff S, Jeffrey P, Bajorath J
J Mol Biol
. 1996 Nov;
263(3):385-9.
PMID: 8918594
The CH1 domains of antibodies belonging to the following five murine immunoglobulin (Ig) classes IgG1, IgG2a, IgG2b, IgG3 and IgA have been compared. The IgG CH1 domain structures are, as...
12.
Chacko S, Silverton E, Davies D, Shick K, Xavier K, Willson R, et al.
Proteins
. 1996 Sep;
26(1):55-65.
PMID: 8880929
The HyHEL-5 antibody has more than a thousandfold lower affinity for bobwhite quail lysozyme (BWQL) than for hen egg-white lysozyme (HEL). Four sequence differences exist between BWQL and HEL, of...
13.
Russo A, Jeffrey P, Pavletich N
Nat Struct Biol
. 1996 Aug;
3(8):696-700.
PMID: 8756328
Cyclin-dependent kinase (CDK)-cyclin complexes require phosphorylation on the CDK subunit for full activation of their Ser/Thr protein kinase activity. The crystal structure of the phosphorylated CDK2-CyclinA-ATP gamma S complex has...
14.
Russo A, Jeffrey P, Patten A, Massague J, Pavletich N
Nature
. 1996 Jul;
382(6589):325-31.
PMID: 8684460
The crystal structure of the human p27Kip1 kinase inhibitory domain bound to the phosphorylated cyclin A-cyclin-dependent kinase 2 (Cdk2) complex has been determined at 2.3 angstrom. p27Kip1 binds the complex...
15.
Sheriff S, Chang C, Jeffrey P, Bajorath J
J Mol Biol
. 1996 Jun;
259(5):938-46.
PMID: 8683596
The X-ray structure of the uncomplexed human chimeric Fab' of the anti-tumor antibody BR96 has been determined at 2.6 A resolution. The structure has been compared with Lewis Y antigen-complexed...
16.
Howitt S, Rodgers A, Jeffrey P, Cox G
J Biol Chem
. 1996 Mar;
271(12):7038-42.
PMID: 8636135
Site-directed mutagenesis was used to investigate the roles of a short series of hydrophobic amino acids in the b-subunit of the Escherichia coli F0F1-ATPase. A mutation affecting one of these,...
17.
Nourse A, Treacy G, Shaw D, Jeffrey P
Biol Chem Hoppe Seyler
. 1996 Feb;
377(2):147-53.
PMID: 8868070
Insulin from a monotreme, the platypus (Ornithorhynchus anatinus), was isolated and the amino acid sequence determined. It differs from pig insulin at eleven amino acid sites, mainly on the surface...
18.
Short M, Jeffrey P, Kwong R, Margolies M
J Biol Chem
. 1995 Dec;
270(48):28541-50.
PMID: 7499368
We constructed a bacteriophage-displayed library containing randomized mutations at H chain residues 30-35 of the anti-digoxin antibody 26-10 Fab to investigate sequence constraints necessary for high affinity binding in an...
19.
Jeffrey P, Russo A, Polyak K, Gibbs E, Hurwitz J, Massague J, et al.
Nature
. 1995 Jul;
376(6538):313-20.
PMID: 7630397
The crystal structure of the human cyclinA-cyclin-dependent kinase2 (CDK2)-ATP complex has been determined at 2.3 A resolution. CyclinA binds to one side of CDK2's catalytic cleft, inducing large conformational changes...
20.
Jeffrey P, Bajorath J, Chang C, Yelton D, Hellstrom I, Hellstrom K, et al.
Nat Struct Biol
. 1995 Jun;
2(6):466-71.
PMID: 7664109
The crystal structures of the murine BR96 Fab and its human chimera have been determined in complex with the nonoate methyl ester derivative of Lewis Y (nLey) at 2.8 A...