P C Familletti
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Explore the profile of P C Familletti including associated specialties, affiliations and a list of published articles.
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39
Citations
1484
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Recent Articles
1.
Gately M, Carvajal D, Connaughton S, Gillessen S, Warrier R, Kolinsky K, et al.
Ann N Y Acad Sci
. 1996 Oct;
795:1-12.
PMID: 8958912
Mo(p40)2 is a potent IL-12 antagonist that interacts strongly with the beta 1 subunit of the IL-12R to block binding of moIL-12 to the high-affinity mouse IL-12R. Mo(p40)2, alone or...
2.
Gillessen S, Carvajal D, Ling P, Podlaski F, Stremlo D, Familletti P, et al.
Eur J Immunol
. 1995 Jan;
25(1):200-6.
PMID: 7843232
Interleukin-12 (IL-12) is a cytokine that has regulatory effects on T and natural killer (NK) cells and is composed of two disulfide-bonded subunits, p40 and p35. It was recently reported...
3.
Tinubu S, Hakimi J, Kondas J, Bailon P, Familletti P, Spence C, et al.
J Immunol
. 1994 Nov;
153(9):4330-8.
PMID: 7930631
IL-2Rs are expressed by T cells activated in response to foreign histocompatibility Ags but not by normal cells. This difference in IL-2R expression is exploited by blockade of IL-2Rs to...
4.
Li S, Burns D, Rumberger J, Presky D, Wilkinson V, Anostario Jr M, et al.
J Biol Chem
. 1994 Feb;
269(6):4431-7.
PMID: 7508442
To study the structural characteristics of E-selectin necessary for mediating cell adhesion, we examined the role of the consensus repeat (CR) domains in E-selectin function. Soluble constructs containing different numbers...
5.
Graves B, Crowther R, Chandran C, Rumberger J, Li S, Huang K, et al.
Nature
. 1994 Feb;
367(6463):532-8.
PMID: 7509040
The three-dimensional structure of the ligand-binding region of human E-selectin has been determined at 2.0 A resolution. The structure reveals limited contact between the two domains and a coordination of...
6.
Kao J, Ryan J, Brett G, Chen J, Shen H, Fan Y, et al.
J Biol Chem
. 1992 Oct;
267(28):20239-47.
PMID: 1400342
An important means by which tumor cells influence the vasculature is through the production of soluble mediators altering vascular properties. A approximately 22-kDa polypeptide was purified to homogeneity from conditioned...
7.
Schoenhaut D, Chua A, Wolitzky A, Quinn P, Dwyer C, McComas W, et al.
J Immunol
. 1992 Jun;
148(11):3433-40.
PMID: 1350290
Human IL-12 (NK cell stimulatory factor, cytotoxic lymphocyte maturation factor) is a heterodimeric cytokine that can act as a growth factor for activated human T and NK cells, enhance the...
8.
Levin W, Daniel R, Stoner C, Stoller T, Angelillo Y, Familletti P, et al.
Protein Expr Purif
. 1992 Feb;
3(1):27-35.
PMID: 1422206
Recombinant human secretory phospholipase A2 (Group II) was expressed in long-term culture of immobilized Chinese hamster ovary cells utilizing a continuous-perfusion airlift bioreactor. The bioreactor was continuously perfused with cell-culture...
9.
Hakimi J, Chizzonite R, Luke D, Familletti P, Bailon P, Kondas J, et al.
J Immunol
. 1991 Aug;
147(4):1352-9.
PMID: 1869828
The anti-Tac mAb has been shown to bind to the p55 chain of the IL-2R, block IL-2 binding and inhibit T cell proliferation. A humanized form of anti-Tac (HAT) has...
10.
Gately M, Desai B, Wolitzky A, Quinn P, Dwyer C, Podlaski F, et al.
J Immunol
. 1991 Aug;
147(3):874-82.
PMID: 1713608
IL-12 is a heterodimeric cytokine that was identified on the basis of its ability to synergize with IL-2 in the induction of cytotoxic effector cells and was originally called cytotoxic...