P A Hossler
Overview
Explore the profile of P A Hossler including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
337
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Recent Articles
1.
Meshnick S, Hossler P, Enger K, Kazanjian P, Rest J, Mindell D, et al.
J Eukaryot Microbiol
. 2002 Mar;
Suppl:126S-128S.
PMID: 11906022
No abstract available.
2.
Kazanjian P, Armstrong W, Hossler P, Lee C, Huang L, Beard C, et al.
J Infect Dis
. 2001 Feb;
183(5):819-22.
PMID: 11181161
This retrospective cohort study was conducted to determine whether Pneumocystis carinii cytochrome b gene mutations in patients with AIDS and P. carinii pneumonia (PCP) are associated with atovaquone exposure. Portions...
3.
Kazanjian P, Armstrong W, Hossler P, Burman W, Richardson J, Lee C, et al.
J Infect Dis
. 2000 Jul;
182(2):551-7.
PMID: 10915088
This study was conducted to determine whether Pneumocystis carinii dyhydropteroate synthase (DHPS) gene mutations in AIDS patients with P. carinii pneumonia (PCP) are affected by duration of sulfa or sulfone...
4.
Moormann A, Hossler P, Meshnick S
Mol Biochem Parasitol
. 1999 Mar;
98(2):279-83.
PMID: 10080396
No abstract available.
5.
Walker D, Wakefield A, Dohn M, Miller R, Baughman R, Hossler P, et al.
J Infect Dis
. 1998 Nov;
178(6):1767-75.
PMID: 9815231
Atovaquone (Mepron, 566c80) is an effective agent against Pneumocystis carinii, which probably acts by binding to cytochrome b and inhibiting electron transport. To assess the possibility that atovaquone resistance might...
6.
Bhisutthibhan J, Pan X, Hossler P, Walker D, Yowell C, Carlton J, et al.
J Biol Chem
. 1998 Jun;
273(26):16192-8.
PMID: 9632675
Artemisinin and its derivatives are important new antimalarial drugs. When Plasmodium falciparum-infected erythrocytes are incubated with [10-3H]dihydroartemisinin, several malaria-specific proteins become labeled. One of these proteins is the P. falciparum...
7.
Kazanjian P, Locke A, Hossler P, Lane B, Bartlett M, Smith J, et al.
AIDS
. 1998 Jun;
12(8):873-8.
PMID: 9631140
Background: Failures of prophylaxis against Pneumocystis carinii pneumonia (PCP) in AIDS patients do occur, but no evidence for drug resistance has yet been presented. Objective: To determine whether mutations in...
8.
Castor C, Smith E, Bignall M, Hossler P
J Rheumatol
. 1998 Feb;
24(11):2080-9.
PMID: 9375864
Objective: Since many cytokines have been identified in chronically inflamed human synovium, it is possible that particular cytokines or combinations of cytokines play dominant roles in driving or inhibiting metabolic...
9.
Lane B, Ast J, Hossler P, Mindell D, Bartlett M, Smith J, et al.
J Infect Dis
. 1997 Feb;
175(2):482-5.
PMID: 9203679
Sulfa drugs are widely used in the treatment and prophylaxis of Pneumocystis carinii pneumonia. The nucleotide sequences of the sulfa target enzyme, dihydropteroate synthase (DHPS), differed substantially in human-, rat-,...
10.
Hong Y, Hossler P, Calhoun D, Meshnick S
Antimicrob Agents Chemother
. 1995 Aug;
39(8):1756-63.
PMID: 7486915
Forty-four sulfa drugs were screened against crude preparations of recombinant Pneumocystis carinii dihydropteroate synthetase. The apparent Michaelis-Menten constants (Km) for p-aminobenzoic acid and 7,8-dihydro-6-hydroxymethylpterin pyrophosphate were 0.34 +/- 0.02 and...