Owen Rackham
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Explore the profile of Owen Rackham including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
1588
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0
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Recent Articles
1.
Deutsch E, Kok L, Mudge J, Ruiz-Orera J, Fierro-Monti I, Sun Z, et al.
bioRxiv
. 2024 Sep;
PMID: 39314370
A major scientific drive is to characterize the protein-coding genome as it provides the primary basis for the study of human health. But the fundamental question remains: what has been...
2.
Chothani S, Ho L, Schafer S, Rackham O
RNA Biol
. 2023 Nov;
20(1):943-954.
PMID: 38013207
Building a reference set of protein-coding open reading frames (ORFs) has revolutionized biological process discovery and understanding. Traditionally, gene models have been confirmed using cDNA sequencing and encoded translated regions...
3.
Krishnan V, Schmidt F, Nawaz Z, Venkatesh P, Lee K, Ren X, et al.
Blood
. 2023 Mar;
141(22):2738-2755.
PMID: 36857629
Primary resistance to tyrosine kinase inhibitors (TKIs) is a significant barrier to optimal outcomes in chronic myeloid leukemia (CML), but factors contributing to response heterogeneity remain unclear. Using single-cell RNA...
4.
Whiffin N, Karczewski K, Zhang X, Chothani S, Smith M, Evans D, et al.
Nat Commun
. 2021 Feb;
12(1):839.
PMID: 33531501
No abstract available.
5.
Rackham O, Cahan P, Mah N, Morris S, Ouyang J, Plant A, et al.
Stem Cell Reports
. 2021 Jan;
16(1):3-9.
PMID: 33440181
The first meetup for Computational Stem Cell Biologists was held at the 2020 annual meeting of the International Society for Stem Cell Research. The discussions highlighted opportunities and barriers to...
6.
Whiffin N, Karczewski K, Zhang X, Chothani S, Smith M, Evans D, et al.
Nat Commun
. 2020 May;
11(1):2523.
PMID: 32461616
Upstream open reading frames (uORFs) are tissue-specific cis-regulators of protein translation. Isolated reports have shown that variants that create or disrupt uORFs can cause disease. Here, in a systematic genome-wide...
7.
Lizio M, Harshbarger J, Abugessaisa I, Noguchi S, Kondo A, Severin J, et al.
Nucleic Acids Res
. 2016 Oct;
45(D1):D737-D743.
PMID: 27794045
Upon the first publication of the fifth iteration of the Functional Annotation of Mammalian Genomes collaborative project, FANTOM5, we gathered a series of primary data and database systems into the...
8.
Andersson R, Gebhard C, Miguel-Escalada I, Hoof I, Bornholdt J, Boyd M, et al.
Nature
. 2014 Mar;
507(7493):455-461.
PMID: 24670763
Enhancers control the correct temporal and cell-type-specific activation of gene expression in multicellular eukaryotes. Knowing their properties, regulatory activity and targets is crucial to understand the regulation of differentiation and...