Owen Pornillos
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Explore the profile of Owen Pornillos including associated specialties, affiliations and a list of published articles.
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52
Citations
3255
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Recent Articles
31.
Sanchez J, Chiang J, Sparrer K, Alam S, Chi M, Roganowicz M, et al.
Cell Rep
. 2016 Jul;
16(5):1315-1325.
PMID: 27425606
Antiviral response pathways induce interferon by higher-order assembly of signaling complexes called signalosomes. Assembly of the RIG-I signalosome is regulated by K63-linked polyubiquitin chains, which are synthesized by the E3...
32.
Wagner J, Zadrozny K, Chrustowicz J, Purdy M, Yeager M, Ganser-Pornillos B, et al.
Elife
. 2016 Jul;
5.
PMID: 27416583
Virus assembly and maturation proceed through the programmed operation of molecular switches, which trigger both local and global structural rearrangements to produce infectious particles. HIV-1 contains an assembly and maturation...
33.
Li Y, Chandrasekaran V, Carter S, Woodward C, Christensen D, Dryden K, et al.
Elife
. 2016 Jun;
5.
PMID: 27253068
TRIM5 proteins are restriction factors that block retroviral infections by binding viral capsids and preventing reverse transcription. Capsid recognition is mediated by C-terminal domains on TRIM5α (SPRY) or TRIMCyp (cyclophilin...
34.
Wagner J, Roganowicz M, Skorupka K, Alam S, Christensen D, Doss G, et al.
Elife
. 2016 Jun;
5.
PMID: 27253059
Restriction factors and pattern recognition receptors are important components of intrinsic cellular defenses against viral infection. Mammalian TRIM5α proteins are restriction factors and receptors that target the capsid cores of...
35.
Gres A, Kirby K, KewalRamani V, Tanner J, Pornillos O, Sarafianos S
Science
. 2015 Jun;
349(6243):99-103.
PMID: 26044298
The detailed molecular interactions between native HIV-1 capsid protein (CA) hexamers that shield the viral genome and proteins have been elusive. We report crystal structures describing interactions between CA monomers...
36.
Bhattacharya A, Alam S, Fricke T, Zadrozny K, Sedzicki J, Taylor A, et al.
Proc Natl Acad Sci U S A
. 2014 Dec;
111(52):18625-30.
PMID: 25518861
Upon infection of susceptible cells by HIV-1, the conical capsid formed by ∼250 hexamers and 12 pentamers of the CA protein is delivered to the cytoplasm. The capsid shields the...
37.
Sanchez J, Okreglicka K, Chandrasekaran V, Welker J, Sundquist W, Pornillos O
Proc Natl Acad Sci U S A
. 2014 Feb;
111(7):2494-9.
PMID: 24550273
Tripartite motif (TRIM) proteins make up a large family of coiled-coil-containing RING E3 ligases that function in many cellular processes, particularly innate antiviral response pathways. Both dimerization and higher-order assembly...
38.
Ganser-Pornillos B, Yeager M, Pornillos O
Adv Exp Med Biol
. 2012 Feb;
726:441-65.
PMID: 22297526
HIV forms spherical, membrane-enveloped, pleomorphic virions, 1,000-1,500 Å in diameter, which contain two copies of its single-stranded, positive-sense RNA genome. Virus particles initially bud from host cells in a noninfectious...
39.
Pornillos O, Ganser-Pornillos B, Yeager M
Nature
. 2011 Jan;
469(7330):424-7.
PMID: 21248851
The mature capsids of human immunodeficiency virus type 1 (HIV-1) and other retroviruses are fullerene shells, composed of the viral CA protein, that enclose the viral genome and facilitate its...
40.
Ganser-Pornillos B, Chandrasekaran V, Pornillos O, Sodroski J, Sundquist W, Yeager M
Proc Natl Acad Sci U S A
. 2010 Dec;
108(2):534-9.
PMID: 21187419
TRIM5α proteins are restriction factors that protect mammalian cells from retroviral infections by binding incoming viral capsids, accelerating their dissociation, and preventing reverse transcription of the viral genome. Individual TRIM5...