Owen Pornillos
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Explore the profile of Owen Pornillos including associated specialties, affiliations and a list of published articles.
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52
Citations
3255
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Recent Articles
11.
Eschbach J, Elliott J, Li W, Zadrozny K, Davis K, Mohammed S, et al.
J Virol
. 2020 Oct;
95(2).
PMID: 33115869
The human immunodeficiency virus type 1 (HIV-1) capsid (CA) protein forms a conical lattice around the viral ribonucleoprotein complex (vRNP) consisting of a dimeric viral genome and associated proteins, together...
12.
Christensen D, Ganser-Pornillos B, Johnson J, Pornillos O, Sundquist W
Science
. 2020 Oct;
370(6513).
PMID: 33033190
During the first half of the viral life cycle, HIV-1 reverse transcribes its RNA genome and integrates the double-stranded DNA copy into a host cell chromosome. Despite progress in characterizing...
13.
Ward A, Kiessling V, Pornillos O, White J, Ganser-Pornillos B, Tamm L
J Biol Chem
. 2020 Aug;
295(45):15183-15195.
PMID: 32788212
To enter a cell and establish infection, HIV must first fuse its lipid envelope with the host cell plasma membrane. Whereas the process of HIV membrane fusion can be tracked...
14.
Yu A, Skorupka K, Pak A, Ganser-Pornillos B, Pornillos O, Voth G
Nat Commun
. 2020 Mar;
11(1):1307.
PMID: 32161265
The tripartite-motif protein, TRIM5α, is an innate immune sensor that potently restricts retrovirus infection by binding to human immunodeficiency virus capsids. Higher-ordered oligomerization of this protein forms hexagonally patterned structures...
15.
Skorupka K, Roganowicz M, Christensen D, Wan Y, Pornillos O, Ganser-Pornillos B
Sci Adv
. 2019 Dec;
5(11):eaaw3631.
PMID: 31807695
TRIM5α is a restriction factor that senses incoming retrovirus cores through an unprecedented mechanism of nonself recognition. TRIM5α assembles a hexagonal lattice that avidly binds the capsid shell, which surrounds...
16.
Kucharska I, Ding P, Zadrozny K, Dick R, Summers M, Ganser-Pornillos B, et al.
J Virol
. 2019 Dec;
94(5).
PMID: 31801870
The assembly of an orthoretrovirus such as HIV-1 requires the coordinated functioning of multiple biochemical activities of the viral Gag protein. These activities include membrane targeting, lattice formation, packaging of...
17.
Kueck T, Bloyet L, Cassella E, Zang T, Schmidt F, Brusic V, et al.
J Virol
. 2019 Oct;
93(24).
PMID: 31578292
Interferons (IFNs) induce the expression of interferon-stimulated genes (ISGs), many of which are responsible for the cellular antiviral state in which the replication of numerous viruses is blocked. How the...
18.
Ganser-Pornillos B, Pornillos O
Nat Rev Microbiol
. 2019 Jul;
17(9):546-556.
PMID: 31312031
Mammalian cells express a variety of innate immune proteins - known as restriction factors - which defend against invading retroviruses such as HIV-1. Two members of the tripartite motif protein...
19.
Pornillos O, Ganser-Pornillos B
Curr Opin Virol
. 2019 Jun;
36:47-55.
PMID: 31185449
During retrovirus maturation, cleavage of the precursor structural Gag polyprotein by the viral protease induces architectural rearrangement of the virus particle from an immature into a mature, infectious form. The...
20.
Stevens M, Franke B, Skorupka K, Cafiso D, Pornillos O, Mayans O, et al.
J Mol Biol
. 2019 May;
431(15):2900-2909.
PMID: 31125568
MuRF1 (TRIM63) is a RING-type E3 ubiquitin ligase with a predicted tripartite TRIM fold. TRIM proteins rely upon the correct placement of an N-terminal RING domain, with respect to C-terminal,...