Orane Visvikis
Overview
Explore the profile of Orane Visvikis including associated specialties, affiliations and a list of published articles.
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Articles
21
Citations
1555
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Recent Articles
1.
Garcia-Sanchez J, Bonnet E, Loubatier C, Doye A, Paillier G, Segui F, et al.
iScience
. 2025 Feb;
28(2):111838.
PMID: 39995862
Transcription factor EB (TFEB) is a key transcription factor that orchestrates the cellular response to stress. Dysregulation of TFEB is associated with a range of human diseases, and understanding the...
2.
Doye A, Chaintreuil P, Lagresle-Peyrou C, Batistic L, Marion V, Munro P, et al.
J Exp Med
. 2024 Aug;
221(10).
PMID: 39212656
A growing number of patients presenting severe combined immunodeficiencies attributed to monoallelic RAC2 variants have been identified. The expression of the RHO GTPase RAC2 is restricted to the hematopoietic lineage....
3.
Niu T, De Rosny C, Chautard S, Rey A, Patoli D, Groslambert M, et al.
Nat Commun
. 2021 Oct;
12(1):5862.
PMID: 34615873
NLRP3 controls the secretion of inflammatory cytokines IL-1β/18 and pyroptosis by assembling the inflammasome. Upon coordinated priming and activation stimuli, NLRP3 recruits NEK7 within hetero-oligomers that nucleate ASC and caspase-1...
4.
Courjon J, Dufies O, Robert A, Bailly L, Torre C, Chirio D, et al.
Blood Adv
. 2021 Mar;
5(5):1523-1534.
PMID: 33683342
Dysregulated immune response is the key factor leading to unfavorable coronavirus disease 2019 (COVID-19) outcome. Depending on the pathogen-associated molecular pattern, the NLRP3 inflammasome can play a crucial role during...
5.
Garcia-Sanchez J, Ewbank J, Visvikis O
Cell Mol Life Sci
. 2021 Feb;
78(9):4305-4333.
PMID: 33630111
Innate immunity is an evolutionary ancient defence strategy that serves to eliminate infectious agents while maintaining host health. It involves a complex network of sensors, signaling proteins and immune effectors...
6.
Dufies O, Doye A, Courjon J, Torre C, Michel G, Loubatier C, et al.
Nat Microbiol
. 2021 Jan;
6(3):401-412.
PMID: 33432150
Inflammasomes are signalling platforms that are assembled in response to infection or sterile inflammation by cytosolic pattern recognition receptors. The consequent inflammasome-triggered caspase-1 activation is critical for the host defence...
7.
Acosta M, Urbach S, Doye A, Ng Y, Boudeau J, Mettouchi A, et al.
Sci Rep
. 2018 Jan;
8(1):1410.
PMID: 29362425
The regulation of Rac1 by HACE1-mediated ubiquitination and proteasomal degradation is emerging as an essential element in the maintenance of cell homeostasis. However, how the E3 ubiquitin ligase activity of...
8.
Mahtal N, Brewee C, Pichard S, Visvikis O, Cintrat J, Barbier J, et al.
ChemMedChem
. 2018 Jan;
13(7):754-761.
PMID: 29359495
Cytotoxic necrotizing factor 1 (CNF1) is a toxin produced by pathogenic strains of Escherichia coli responsible for extra-intestinal infections. CNF1 deamidates Rac1, thereby triggering its permanent activation and worsening inflammatory...
9.
Ngba Essebe C, Visvikis O, Fines-Guyon M, Vergne A, Cattoir V, Lecoustumier A, et al.
Front Cell Infect Microbiol
. 2017 Apr;
7:77.
PMID: 28361041
Social bacterial interactions are considered essential in numerous infectious diseases, particularly in wounds. Foot ulcers are a common complication in diabetic patients and these ulcers become frequently infected. This infection...
10.
Najibi M, Labed S, Visvikis O, Irazoqui J
Cell Rep
. 2016 May;
15(8):1728-42.
PMID: 27184844
The mechanisms that tightly control the transcription of host defense genes have not been fully elucidated. We previously identified TFEB as a transcription factor important for host defense, but the...