Onuralp Soylemez
Overview
Explore the profile of Onuralp Soylemez including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
361
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0
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Recent Articles
1.
Bendapudi P, Nazeen S, Ryu J, Soylemez O, Robbins A, Rouaisnel B, et al.
Blood
. 2023 Dec;
143(11):1032-1044.
PMID: 38096369
Extreme disease phenotypes can provide key insights into the pathophysiology of common conditions, but studying such cases is challenging due to their rarity and the limited statistical power of existing...
2.
Kousi M, Soylemez O, Ozanturk A, Mourtzi N, Akle S, Jungreis I, et al.
Nat Genet
. 2020 Oct;
52(11):1145-1150.
PMID: 33046855
The influence of genetic background on driver mutations is well established; however, the mechanisms by which the background interacts with Mendelian loci remain unclear. We performed a systematic secondary-variant burden...
3.
Haghighi A, Krier J, Toth-Petroczy A, Cassa C, Frank N, Carmichael N, et al.
NPJ Genom Med
. 2018 Aug;
3:21.
PMID: 30131872
Despite major progress in defining the genetic basis of Mendelian disorders, the molecular etiology of many cases remains unknown. Patients with these undiagnosed disorders often have complex presentations and require...
4.
Howe K, Schiffer P, Zielinski J, Wiehe T, Laird G, Marioni J, et al.
Open Biol
. 2016 Jun;
6(4):160009.
PMID: 27248802
Multicellular eukaryotes have evolved a range of mechanisms for immune recognition. A widespread family involved in innate immunity are the NACHT-domain and leucine-rich-repeat-containing (NLR) proteins. Mammals have small numbers of...
5.
Sarkisyan K, Bolotin D, Meer M, Usmanova D, Mishin A, Sharonov G, et al.
Nature
. 2016 May;
533(7603):397-401.
PMID: 27193686
Fitness landscapes depict how genotypes manifest at the phenotypic level and form the basis of our understanding of many areas of biology, yet their properties remain elusive. Previous studies have...
6.
Kretz C, Dai M, Soylemez O, Yee A, Desch K, Siemieniak D, et al.
Proc Natl Acad Sci U S A
. 2015 Jul;
112(30):9328-33.
PMID: 26170332
Proteases play important roles in many biologic processes and are key mediators of cancer, inflammation, and thrombosis. However, comprehensive and quantitative techniques to define the substrate specificity profile of proteases...
7.
Soylemez O, Kondrashov F
Genome Biol Evol
. 2012 Nov;
4(12):1213-22.
PMID: 23132897
Whether or not evolutionary change is inherently irreversible remains a controversial topic. Some examples of evolutionary irreversibility are known; however, this question has not been comprehensively addressed at the molecular...