Oliver M Russell
Overview
Explore the profile of Oliver M Russell including associated specialties, affiliations and a list of published articles.
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13
Citations
376
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Recent Articles
1.
Hipps D, Pyle A, Porter A, Dobson P, Tuppen H, Lawless C, et al.
Sci Rep
. 2024 Sep;
14(1):20989.
PMID: 39251776
Heteroplasmic mitochondrial DNA (mtDNA) variants accumulate as humans age, particularly in the stem-cell compartments, and are an important contributor to age-related disease. Mitochondrial dysfunction has been observed in osteoporosis and...
2.
Franklin I, Milne P, Childs J, Boggan R, Barrow I, Lawless C, et al.
Life Sci Alliance
. 2023 Aug;
6(11).
PMID: 37652671
Pathogenic mitochondrial DNA (mtDNA) single-nucleotide variants are a common cause of adult mitochondrial disease. Levels of some variants decrease with age in blood. Given differing division rates, longevity, and energetic...
3.
Di Leo V, Lawless C, Roussel M, Gomes T, Gorman G, Russell O, et al.
J Neuromuscul Dis
. 2023 Aug;
10(6):1111-1126.
PMID: 37638448
Background: Myotonic dystrophy type 1 (DM1) is a dominant autosomal neuromuscular disorder caused by the inheritance of a CTG triplet repeat expansion in the Dystrophia Myotonica Protein Kinase (DMPK) gene....
4.
PINK1-Dependent Mitophagy Inhibits Elevated Ubiquitin Phosphorylation Caused by Mitochondrial Damage
Lambourne O, Bell S, Wilhelm L, Yarbrough E, Holly G, Russell O, et al.
J Med Chem
. 2023 May;
66(11):7645-7656.
PMID: 37248632
Ubiquitin phosphorylation by the mitochondrial protein kinase PTEN-induced kinase 1 (PINK1), upon mitochondrial depolarization, is an important intermediate step in the recycling of damaged mitochondria via mitophagy. As mutations in...
5.
Nolden K, Egner J, Collier J, Russell O, Alston C, Harwig M, et al.
Life Sci Alliance
. 2022 Aug;
5(12).
PMID: 35914810
Imbalances in mitochondrial and peroxisomal dynamics are associated with a spectrum of human neurological disorders. Mitochondrial and peroxisomal fission both involve dynamin-related protein 1 (DRP1) oligomerisation and membrane constriction, although...
6.
Smith A, Whitehall J, Bradshaw C, Gay D, Robertson F, Blain A, et al.
Nat Cancer
. 2022 Feb;
2(1):129.
PMID: 35121898
No abstract available.
7.
Smith A, Whitehall J, Bradshaw C, Gay D, Robertson F, Blain A, et al.
Nat Cancer
. 2020 Oct;
1(10):976-989.
PMID: 33073241
Oxidative phosphorylation (OXPHOS) defects caused by somatic mitochondrial DNA (mtDNA) mutations increase with age in human colorectal epithelium and are prevalent in colorectal tumours, but whether they actively contribute to...
8.
Lightowlers R, Chrzanowska-Lightowlers Z, Russell O
EMBO Rep
. 2020 Aug;
21(9):e50964.
PMID: 32852136
Transplantation of functional mitochondria directly into defective cells is a novel approach that has recently caught the attention of scientists and the general public alike. Could this be too good...
9.
Russell O, Gorman G, Lightowlers R, Turnbull D
Cell
. 2020 Mar;
181(1):168-188.
PMID: 32220313
Mitochondrial diseases are clinically heterogeneous disorders caused by a wide spectrum of mutations in genes encoded by either the nuclear or the mitochondrial genome. Treatments for mitochondrial diseases are currently...
10.
Ahmed S, Craven L, Russell O, Turnbull D, Vincent A
Neurotherapeutics
. 2018 Nov;
15(4):943-953.
PMID: 30406383
Mitochondrial myopathies are progressive muscle conditions caused primarily by the impairment of oxidative phosphorylation (OXPHOS) in the mitochondria. This causes a deficit in energy production in the form of adenosine...