Oleksandr Platoshyn
Overview
Explore the profile of Oleksandr Platoshyn including associated specialties, affiliations and a list of published articles.
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53
Citations
3128
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Recent Articles
1.
Lopez-Erauskin J, Bravo-Hernandez M, Presa M, Baughn M, Melamed Z, Beccari M, et al.
Nat Neurosci
. 2023 Nov;
27(1):34-47.
PMID: 37996528
The mRNA transcript of the human STMN2 gene, encoding for stathmin-2 protein (also called SCG10), is profoundly impacted by TAR DNA-binding protein 43 (TDP-43) loss of function. The latter is...
2.
Kobayashi Y, Shigyo M, Platoshyn O, Marsala S, Kato Jr T, Takamura N, et al.
Cell Transplant
. 2023 Apr;
32:9636897221107009.
PMID: 37088987
One of the challenges in clinical translation of cell-replacement therapies is the definition of optimal cell generation and storage/recovery protocols which would permit a rapid preparation of cell-treatment products for...
3.
Shigyo M, Kobayashi Y, Platoshyn O, Marsala S, Kato Jr T, Takamura N, et al.
Cell Transplant
. 2023 Mar;
32:9636897231163232.
PMID: 36959733
The critical requirements in developing clinical-grade human-induced pluripotent stem cells-derived neural precursors (hiPSCs-NPCs) are defined by expandability, genetic stability, predictable post-grafting differentiation, and acceptable safety profile. Here, we report on...
4.
Tadokoro T, Bravo-Hernandez M, Agashkov K, Kobayashi Y, Platoshyn O, Navarro M, et al.
Mol Ther
. 2022 May;
30(8):2722-2745.
PMID: 35524407
Second-order spinal cord excitatory neurons play a key role in spinal processing and transmission of pain signals to the brain. Exogenously induced change in developmentally imprinted excitatory neurotransmitter phenotypes of...
5.
Batra R, Nelles D, Roth D, Krach F, Nutter C, Tadokoro T, et al.
Nat Biomed Eng
. 2020 Sep;
5(2):157-168.
PMID: 32929188
Myotonic dystrophy type I (DM1) is a multisystemic autosomal-dominant inherited human disorder that is caused by CTG microsatellite repeat expansions (MREs) in the 3' untranslated region of DMPK. Toxic RNAs...
6.
Bravo-Hernandez M, Tadokoro T, Navarro M, Platoshyn O, Kobayashi Y, Marsala S, et al.
Nat Med
. 2019 Dec;
26(1):118-130.
PMID: 31873312
Gene silencing with virally delivered shRNA represents a promising approach for treatment of inherited neurodegenerative disorders. In the present study we develop a subpial technique, which we show in adult...
7.
Sawada A, Wang S, Jian M, Leem J, Wackerbarth J, Egawa J, et al.
FASEB J
. 2019 Mar;
33(6):7545-7554.
PMID: 30894019
Interventions that preserve motor neurons or restore functional motor neuroplasticity may extend longevity in amyotrophic lateral sclerosis (ALS). Delivery of neurotrophins may potentially revive degenerating motor neurons, yet this approach...
8.
Bohaciakova D, Hruska-Plochan M, Tsunemoto R, Gifford W, Driscoll S, Glenn T, et al.
Stem Cell Res Ther
. 2019 Mar;
10(1):83.
PMID: 30867054
Background: A well-characterized method has not yet been established to reproducibly, efficiently, and safely isolate large numbers of clinical-grade multipotent human neural stem cells (hNSCs) from embryonic stem cells (hESCs)....
9.
Ling S, Ghosh Dastidar S, Tokunaga S, Ho W, Lim K, Ilieva H, et al.
Elife
. 2019 Feb;
8.
PMID: 30747709
Mutations in coding and non-coding regions of FUS cause amyotrophic lateral sclerosis (ALS). The latter mutations may exert toxicity by increasing FUS accumulation. We show here that broad expression within...
10.
Koffler J, Zhu W, Qu X, Platoshyn O, Dulin J, Brock J, et al.
Nat Med
. 2019 Jan;
25(2):263-269.
PMID: 30643285
Current methods for bioprinting functional tissue lack appropriate biofabrication techniques to build complex 3D microarchitectures essential for guiding cell growth and promoting tissue maturation. 3D printing of central nervous system...