Oleg Klykov
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Explore the profile of Oleg Klykov including associated specialties, affiliations and a list of published articles.
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12
Citations
342
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Recent Articles
1.
Klykov O, Bobe D, Paraan M, Johnston J, Potter C, Carragher B, et al.
Bio Protoc
. 2023 Jan;
12(21).
PMID: 36618877
Cryo-focused ion beam (FIB) milling of vitrified specimens is emerging as a powerful method for in situ specimen preparation. It allows for the preservation of native and near-native conditions in...
2.
Kelley K, Raczkowski A, Klykov O, Jaroenlak P, Bobe D, Kopylov M, et al.
Nat Commun
. 2022 Apr;
13(1):1857.
PMID: 35387991
Cryo-FIB/SEM combined with cryo-ET has emerged from within the field of cryo-EM as the method for obtaining the highest resolution structural information of complex biological samples in-situ in native and...
3.
Klykov O, Kopylov M, Carragher B, Heck A, Noble A, Scheltema R
Mol Cell
. 2022 Jan;
82(2):285-303.
PMID: 35063097
Combining diverse experimental structural and interactomic methods allows for the construction of comprehensible molecular encyclopedias of biological systems. Typically, this involves merging several independent approaches that provide complementary structural and...
4.
Klykov O, Gangwar S, Yelshanskaya M, Yen L, Sobolevsky A
Mol Cell
. 2021 Oct;
81(23):4771-4783.e7.
PMID: 34678168
AMPA receptors (AMPARs) mediate the majority of excitatory neurotransmission. Their surface expression, trafficking, gating, and pharmacology are regulated by auxiliary subunits. Of the two types of TARP auxiliary subunits, type...
5.
Zeronian M, Klykov O, Portell I de Montserrat J, Konijnenberg M, Gaur A, Scheltema R, et al.
Proc Natl Acad Sci U S A
. 2021 Jul;
118(30).
PMID: 34301900
The Notch signaling system links cellular fate to that of its neighbors, driving proliferation, apoptosis, and cell differentiation in metazoans, whereas dysfunction leads to debilitating developmental disorders and cancers. Other...
6.
Green M, Gangwar S, Michard E, Simon A, Portes M, Barbosa-Caro J, et al.
Mol Cell
. 2021 Jun;
81(15):3216-3226.e8.
PMID: 34161757
Glutamate receptor-like channels (GLRs) play vital roles in various physiological processes in plants, such as wound response, stomatal aperture control, seed germination, root development, innate immune response, pollen tube growth,...
7.
Klykov O, van der Zwaan C, Heck A, Meijer A, Scheltema R
Proc Natl Acad Sci U S A
. 2020 Jan;
117(4):1976-1987.
PMID: 31924745
Upon activation, fibrinogen forms large fibrin biopolymers that coalesce into clots which assist in wound healing. Limited insights into their molecular architecture, due to the sheer size and the insoluble...
8.
Iacobucci C, Piotrowski C, Aebersold R, Amaral B, Andrews P, Bernfur K, et al.
Anal Chem
. 2019 May;
91(11):6953-6961.
PMID: 31045356
The number of publications in the field of chemical cross-linking combined with mass spectrometry (XL-MS) to derive constraints for protein three-dimensional structure modeling and to probe protein-protein interactions has increased...
9.
de Graaf S, Klykov O, van den Toorn H, Scheltema R
J Proteome Res
. 2018 Dec;
18(2):642-651.
PMID: 30575379
Protein interactions enable much more complex behavior than the sum of the individual protein parts would suggest and represents a level of biological complexity requiring full understanding when unravelling cellular...
10.
Klykov O, Steigenberger B, Pektas S, Fasci D, Heck A, Scheltema R
Nat Protoc
. 2018 Nov;
13(12):2964-2990.
PMID: 30446747
Cross-linking mass spectrometry (XL-MS) has received considerable interest, owing to its potential to investigate protein-protein interactions (PPIs) in an unbiased fashion in complex protein mixtures. Recent developments have enabled the...