Olaf Van Den Broek
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Explore the profile of Olaf Van Den Broek including associated specialties, affiliations and a list of published articles.
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6
Citations
113
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Recent Articles
1.
Roel G, Van Den Broek O, Destree O
Int J Dev Biol
. 2017 Mar;
61(1-2):29-34.
PMID: 28287244
In Xenopus gastrula stage embryos, four isoforms of Tcf1 (B, C, D and E) are present with high amino acid sequence conservation compared to fish, mice and human. We studied...
2.
Loregger A, Grandl M, Mejias-Luque R, Allgauer M, Degenhart K, Haselmann V, et al.
Sci Signal
. 2015 Sep;
8(393):ra90.
PMID: 26350900
Given its fundamental role in development and cancer, the Wnt-β-catenin signaling pathway is tightly controlled at multiple levels. RING finger protein 43 (RNF43) is an E3 ubiquitin ligase originally found...
3.
Janssens S, Van Den Broek O, Davenport I, Akkers R, Liu F, Veenstra G, et al.
Int J Dev Biol
. 2013 Apr;
57(1):49-54.
PMID: 23585352
TCF1 belongs to the family of LEF1/TCF transcription factors that regulate gene expression downstream of Wnt/β-catenin signaling, which is crucial for embryonic development and is involved in adult stem cell...
4.
Faro A, Boj S, Ambrosio R, Van Den Broek O, Korving J, Clevers H
Zebrafish
. 2009 Apr;
6(1):59-68.
PMID: 19374549
The Wnt pathway orchestrates cell fate decisions during embryonic development, organogenesis, and adult tissues homeostasis. T-cell factor (Tcf )/lymphoid enhancer-binding factor (Lef) transcription factors are the downstream effectors of canonical...
5.
Liu F, Van Den Broek O, Destree O, Hoppler S
Development
. 2005 Nov;
132(24):5375-85.
PMID: 16291789
Tcf/Lef transcription factors and beta-catenin mediate canonical Wnt signalling, which plays remarkably diverse roles in embryonic development, stem cell renewal and cancer progression. To investigate the molecular mechanisms allowing for...
6.
Roel G, Van Den Broek O, Spieker N, Peterson-Maduro J, Destree O
Gene Expr Patterns
. 2003 Apr;
3(2):123-6.
PMID: 12711535
We report the cloning and expression of Xenopus Tcf-1. The amino acid sequence of Tcf-1 of Xenopus laevis and Xenopus tropicalis is closely related to that of chicken, mouse and...