Stefan Hoppler
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Explore the profile of Stefan Hoppler including associated specialties, affiliations and a list of published articles.
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37
Citations
822
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Recent Articles
1.
Yamamoto T, Kambayashi Y, Otsuka Y, Afouda B, Giuraniuc C, Michiue T, et al.
Elife
. 2022 Aug;
11.
PMID: 35942683
Secreted molecules called morphogens govern tissue patterning in a concentration-dependent manner. However, it is still unclear how reproducible patterning can be achieved with diffusing molecules, especially when that patterning concerns...
2.
Giuraniuc C, Zain S, Ghafoor S, Hoppler S
J Theor Biol
. 2022 Aug;
551-552:111239.
PMID: 35934090
There are two phases of Wnt signalling in early vertebrate embryogenesis: very early, maternal Wnt signalling promotes dorsal development, and slightly later, zygotic Wnt signalling promotes ventral and lateral mesoderm...
3.
Torres-Aguila N, Salonna M, Hoppler S, Ferrier D
Dev Growth Differ
. 2022 Jan;
64(3):120-137.
PMID: 35048372
Wnt signaling is essential during animal development and regeneration, but also plays an important role in diseases such as cancer and diabetes. The canonical Wnt signaling pathway is one of...
4.
Afouda B, Nakamura Y, Shaw S, Charney R, Paraiso K, Blitz I, et al.
iScience
. 2020 Jul;
23(7):101314.
PMID: 32650116
Although Wnt/β-catenin signaling is generally conserved and well understood, the regulatory mechanisms controlling context-specific direct Wnt target gene expression in development and disease are still unclear. The onset of zygotic...
5.
Mayer C, Giclais S, Alsehly F, Hoppler S
Genes (Basel)
. 2020 May;
11(5).
PMID: 32403323
Aberrantly activated Wnt signaling causes cellular transformation that can lead to human colorectal cancer. Wnt signaling is mediated by Lymphoid Enhancer Factor/T-Cell Factor (LEF/TCF) DNA-binding factors. Here we investigate whether...
6.
Hoppler S, Conlon F
Cold Spring Harb Perspect Biol
. 2019 Nov;
12(6).
PMID: 31767648
has been used to study a wide array of developmental processes, benefiting from vast quantities of relatively large, externally developing eggs. is particularly amenable to examining the cardiac system because...
7.
Mazzotta S, Lynch A, Hoppler S
Methods Mol Biol
. 2018 Jul;
1816:67-78.
PMID: 29987811
In vitro generated human cardiomyocytes hold the ultimate promise for heart patients for repair of injured or diseased myocardium, but they also provide experimental models for studying normal cardiomyocyte development,...
8.
Lynch A, Mazzotta S, Hoppler S
Methods Mol Biol
. 2018 Jul;
1816:55-66.
PMID: 29987810
In vitro generated mammalian cardiomyocytes provide experimental models for studying normal mammalian cardiomyocyte development, for disease modeling and for drug development. They also promise to inform future therapeutic strategies for...
9.
Genome-wide transcriptomics analysis of genes regulated by GATA4, 5 and 6 during cardiomyogenesis in
Afouda B, Lynch A, de Paiva Alves E, Hoppler S
Data Brief
. 2018 Jun;
17:559-563.
PMID: 29876429
The transcription factors GATA4, GATA5 and GATA6 play important roles in heart muscle differentiation. The data presented in this article are related to the research article entitled "Genome-wide transcriptomics analysis...
10.
Afouda B, Lynch A, de Paiva Alves E, Hoppler S
Dev Biol
. 2017 Dec;
434(1):108-120.
PMID: 29229250
The transcription factors GATA4, GATA5 and GATA6 are important regulators of heart muscle differentiation (cardiomyogenesis), which function in a partially redundant manner. We identified genes specifically regulated by individual cardiogenic...