Oksana Mashadova
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Explore the profile of Oksana Mashadova including associated specialties, affiliations and a list of published articles.
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10
Citations
511
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Recent Articles
1.
Ferrarone J, Thomas J, Unni A, Zheng Y, Nagiec M, Gardner E, et al.
Proc Natl Acad Sci U S A
. 2024 May;
121(21):e2403685121.
PMID: 38743625
The tumor suppressor LKB1 is a serine/threonine protein kinase that is frequently mutated in human lung adenocarcinoma (LUAD). LKB1 regulates a complex signaling network that is known to control cell...
2.
Ferrarone J, Thomas J, Unni A, Zheng Y, Nagiec M, Gardner E, et al.
bioRxiv
. 2023 Oct;
PMID: 37904985
The tumor suppressor LKB1 is a serine/threonine protein kinase that is frequently mutated in human lung adenocarcinoma (LUAD). LKB1 regulates a complex signaling network that is known to control cell...
3.
Nelson B, Lin L, Kremer D, Sousa C, Cotta-Ramusino C, Myers A, et al.
Cancer Metab
. 2020 Jan;
8:1.
PMID: 31908776
Background: Metabolic programs in cancer cells are influenced by genotype and the tissue of origin. We have previously shown that central carbon metabolism is rewired in pancreatic ductal adenocarcinoma (PDA)...
4.
Wang D, Paddock M, Lundquist M, Sun J, Mashadova O, Amadiume S, et al.
Cell Rep
. 2019 May;
27(7):1991-2001.e5.
PMID: 31091439
Insulin stimulates the conversion of phosphatidylinositol-4,5-bisphosphate (PI(4,5)P) to phosphatidylinositol-3,4,5-trisphosphate (PI(3,4,5)P), which mediates downstream cellular responses. PI(4,5)P is produced by phosphatidylinositol-4-phosphate 5-kinases (PIP5Ks) and by phosphatidylinositol-5-phosphate 4-kinases (PIP4Ks). Here, we show...
5.
Santana-Codina N, Roeth A, Zhang Y, Yang A, Mashadova O, Asara J, et al.
Nat Commun
. 2018 Nov;
9(1):4945.
PMID: 30470748
Oncogenic KRAS is the key driver of pancreatic ductal adenocarcinoma (PDAC). We previously described a role for KRAS in PDAC tumor maintenance through rewiring of cellular metabolism to support proliferation....
6.
Holt M, Assar Z, Zavareh R, Lin L, Anglin J, Mashadova O, et al.
Biochemistry
. 2018 Oct;
57(47):6604-6614.
PMID: 30365304
Pancreatic cancer cells are characterized by deregulated metabolic programs that facilitate growth and resistance to oxidative stress. Among these programs, pancreatic cancers preferentially utilize a metabolic pathway through the enzyme...
7.
Fonseca D, Baquero J, Murphy M, Aruggoda G, Varriano S, Sapienza C, et al.
Mol Cell Biol
. 2017 Nov;
38(4).
PMID: 29180510
The cellular response to DNA damage is an intricate mechanism that involves the interplay among several pathways. In this study, we provide evidence of the roles of the polyadenylation factor...
8.
Shukla S, Purohit V, Mehla K, Gunda V, Chaika N, Vernucci E, et al.
Cancer Cell
. 2017 Sep;
32(3):392.
PMID: 28898700
No abstract available.
9.
Shukla S, Purohit V, Mehla K, Gunda V, Chaika N, Vernucci E, et al.
Cancer Cell
. 2017 Jul;
32(1):71-87.e7.
PMID: 28697344
Poor response to cancer therapy due to resistance remains a clinical challenge. The present study establishes a widely prevalent mechanism of resistance to gemcitabine in pancreatic cancer, whereby increased glycolytic...
10.
Franchi L, Monteleone I, Hao L, Spahr M, Zhao W, Liu X, et al.
J Immunol
. 2017 Mar;
198(7):2735-2746.
PMID: 28242647
Integration of signaling and metabolic pathways enables and sustains lymphocyte function. Whereas metabolic changes occurring during T cell activation are well characterized, the metabolic demands of differentiated T lymphocytes are...