O Gozani
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Explore the profile of O Gozani including associated specialties, affiliations and a list of published articles.
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10
Citations
897
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Recent Articles
1.
Pena P, Hom R, Hung T, Lin H, Kuo A, Wong R, et al.
J Mol Biol
. 2008 Jun;
380(2):303-12.
PMID: 18533182
Inhibitor of growth 1 (ING1) is implicated in oncogenesis, DNA damage repair, and apoptosis. Mutations within the ING1 gene and altered expression levels of ING1 are found in multiple human...
2.
Karuman P, Gozani O, Odze R, Zhou X, Zhu H, Shaw R, et al.
Mol Cell
. 2001 Jun;
7(6):1307-19.
PMID: 11430832
Here, we investigate the mechanism and function of LKB1, a Ser/Thr kinase mutated in Peutz-Jegher syndrome (PJS). We demonstrate that LKB1 physically associates with p53 and regulates specific p53-dependent apoptosis...
3.
Das B, Xia L, Palandjian L, Gozani O, Chyung Y, REED R
Mol Cell Biol
. 1999 Sep;
19(10):6796-802.
PMID: 10490618
SF3b is a U2 snRNP-associated protein complex essential for spliceosome assembly. Although evidence that SF3b contains the spliceosomal proteins SAPs 49, 130, 145, and 155 has accumulated, a protein-mediated association...
4.
Gozani O, Potashkin J, REED R
Mol Cell Biol
. 1998 Jul;
18(8):4752-60.
PMID: 9671485
Base pairing between U2 snRNA and the branchpoint sequence (BPS) is essential for pre-mRNA splicing. Because the metazoan BPS is short and highly degenerate, this interaction alone is insufficient for...
5.
Seghezzi W, Chua K, Shanahan F, Gozani O, REED R, Lees E
Mol Cell Biol
. 1998 Jul;
18(8):4526-36.
PMID: 9671462
Cyclin E-cdk2 is a critical regulator of cell cycle progression from G1 into S phase in mammalian cells. Despite this important function little is known about the downstream targets of...
6.
Wang C, Chua K, Seghezzi W, Lees E, Gozani O, REED R
Genes Dev
. 1998 May;
12(10):1409-14.
PMID: 9585501
The U2 snRNP component SAP 155 contacts pre-mRNA on both sides of the branch site early in spliceosome assembly and is therefore positioned near or at the spliceosome catalytic center....
7.
Chiara M, Gozani O, Bennett M, Palandjian L, REED R
Mol Cell Biol
. 1996 Jul;
16(7):3317-26.
PMID: 8668147
We have carried out a systematic analysis of the proteins that interact with specific intron and exon sequences during each stage of mammalian spliceosome assembly. This was achieved by site-specifically...
8.
Gozani O, Feld R, REED R
Genes Dev
. 1996 Jan;
10(2):233-43.
PMID: 8566756
A critical step in the pre-mRNA splicing reaction is the stable binding of U2 snRNP to the branchpoint sequence (BPS) to form the A complex. The multimeric U2 snRNP protein...
9.
Gozani O, Palandjian L, REED R
Mol Cell Biol
. 1995 Oct;
15(10):5750-6.
PMID: 7565727
Pre-mRNA assembles into spliceosomal complexes in the stepwise pathway E-->A-->B-->C. We show that mutations in the metazoan branchpoint sequence (BPS) have no apparent effect on E complex formation but block...
10.
Gozani O, Patton J, REED R
EMBO J
. 1994 Jul;
13(14):3356-67.
PMID: 8045264
We have isolated and determined the protein composition of the spliceosomal complex C. The pre-mRNA in this complex has undergone catalytic step I, but not step II, of the splicing...