Nyles W Charon
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Explore the profile of Nyles W Charon including associated specialties, affiliations and a list of published articles.
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38
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1140
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Recent Articles
1.
Inhibitors of Lysinoalanine Cross-Linking in the Flagella Hook as Antimicrobials against Spirochetes
Lynch M, Kurniyati K, Deshpande M, Charon N, Li C, Crane B
ACS Chem Biol
. 2025 Feb;
PMID: 40000236
Spirochetes are especially invasive bacteria that are responsible for several human diseases, including Lyme disease, periodontal disease, syphilis, and leptospirosis. Spirochetes rely on an unusual form of motility based on...
2.
Lynch M, Kurniyati K, Deshpande M, Charon N, Li C, Crane B
bioRxiv
. 2024 Nov;
PMID: 39574594
Spirochetes are especially invasive bacteria that are responsible for several human diseases, including Lyme disease, periodontal disease, syphilis and leptospirosis. Spirochetes rely on an unusual form of motility based on...
3.
Lynch M, Deshpande M, Kurniyati K, Zhang K, James M, Miller M, et al.
PNAS Nexus
. 2023 Dec;
2(12):pgad349.
PMID: 38047041
Spirochetes cause Lyme disease, leptospirosis, syphilis, and several other human illnesses. Unlike other bacteria, spirochete flagella are enclosed within the periplasmic space where the filaments distort and push the cell...
4.
Lynch M, Deshpande M, Kyrniyati K, Zhang K, James M, Miller M, et al.
bioRxiv
. 2023 Jul;
PMID: 37398457
Significance Statement: The phylum Spirochaetota contains bacterial pathogens responsible for a variety of diseases, including Lyme disease, syphilis, periodontal disease, and leptospirosis. Motility of these pathogens is a major virulence...
5.
Chang Y, Zhang K, Carroll B, Zhao X, Charon N, Norris S, et al.
Nat Struct Mol Biol
. 2020 Sep;
27(11):1041-1047.
PMID: 32895555
The bacterial flagellar motor can rotate in counterclockwise (CCW) or clockwise (CW) senses, and transitions are controlled by the phosphorylated form of the response regulator CheY (CheY-P). To dissect the...
6.
Lynch M, Miller M, James M, Zhang S, Zhang K, Li C, et al.
Nat Chem Biol
. 2019 Aug;
15(10):959-965.
PMID: 31406373
The flagellar hook protein FlgE from spirochaete bacteria self-catalyzes the formation of an unusual inter-subunit lysinoalanine (Lal) crosslink that is critical for cell motility. Unlike other known examples of Lal...
7.
Kumar B, Miller K, Charon N, Legleiter J
PLoS One
. 2017 Sep;
12(9):e0184648.
PMID: 28898274
Tapping mode atomic force microscopy (AFM) in solution was used to analyze the role of the internally located periplasmic flagella (PFs) of the Lyme disease spirochete Borrelia burgdorferi in withstanding...
8.
Miller M, Miller K, Bian J, James M, Zhang S, Lynch M, et al.
Nat Microbiol
. 2016 Sep;
1(10):16134.
PMID: 27670115
Spirochaetes are bacteria responsible for several serious diseases, including Lyme disease (Borrelia burgdorferi), syphilis (Treponema pallidum) and leptospirosis (Leptospira interrogans), and contribute to periodontal diseases (Treponema denticola)(1). These spirochaetes employ...
9.
Wunder Jr E, Figueira C, Benaroudj N, Hu B, Tong B, Trajtenberg F, et al.
Mol Microbiol
. 2016 Apr;
101(3):457-70.
PMID: 27113476
Leptospira are unique among bacteria based on their helical cell morphology with hook-shaped ends and the presence of periplasmic flagella (PF) with pronounced spontaneous supercoiling. The factors that provoke such...
10.
Zhang K, Liu J, Charon N, Li C
J Bacteriol
. 2015 Dec;
198(4):664-72.
PMID: 26644432
Unlabelled: The Lyme disease spirochete Borrelia burgdorferi has five putative methyl-accepting chemotaxis proteins (MCPs). In this report, we provide evidence that a hypothetical protein, BB0569, is essential for the chemotaxis...