Noriyasu Hirasawa
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Explore the profile of Noriyasu Hirasawa including associated specialties, affiliations and a list of published articles.
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128
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944
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Recent Articles
1.
Ichinohe R, Segawa R, Nakajo T, Hiratsuka M, Yoshii T, Pirabul K, et al.
Exp Dermatol
. 2025 Feb;
34(2):e70061.
PMID: 39957281
In most cases, atopic dermatitis (AD) is induced by allergic inflammation, with antigen penetration into the epithelial tissues of the skin being the first step in AD development. Accordingly, inhibiting...
2.
Segawa R, Sasano Y, Hatakawa Y, Fujisawa Y, Akutsu S, Uchimura M, et al.
Sci Rep
. 2024 Oct;
14(1):23934.
PMID: 39397158
Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV2) infection has forced social changes worldwide. Development of potent antiviral agents is necessary to prevent future pandemics. Titanium oxide, a photocatalyst, is a long-acting antiviral...
3.
Yamazaki S, Hishinuma E, Suzuki Y, Ueda A, Kijogi C, Nakayoshi T, et al.
Biochem Pharmacol
. 2024 Sep;
229:116515.
PMID: 39218044
Cytochrome P450 2B6 (CYP2B6) catalyzes the metabolism of many drugs, including efavirenz and propofol. Genetic polymorphisms in CYP2B6 alter its enzymatic activity and substantially affect its pharmacokinetics. High-frequency variants, such...
4.
Yamamoto R, Segawa R, Kato H, Niino Y, Sato T, Hiratsuka M, et al.
Biochim Biophys Acta Biomembr
. 2024 Jun;
1866(7):184359.
PMID: 38862034
Cytokine receptor-like factor 2 (CRLF2) and interleukin-7 receptor α (IL-7Rα) form a receptor for thymic stromal lymphopoietin (TSLP). A somatic mutation consisting of the substitution of five amino acids (SLLLL)...
5.
Maeyama R, Segawa R, Onodera R, Hiratsuka M, Hirasawa N
Toxicology
. 2023 Dec;
501:153710.
PMID: 38104653
Nickel (Ni) is a typical hapten in allergic contact dermatitis. However, it has been used in various metal materials due to its usefulness. Although Ni ions induce apoptosis of inflammatory...
6.
Fujiwara K, Nagasawa S, Maeyama R, Segawa R, Hirasawa N, Hirokawa T, et al.
Chemistry
. 2023 Nov;
30(11):e202303548.
PMID: 38012076
We herein evaluate a biological applicability of 1,3-substituted cuneanes as an isostere of m-substituted benzenes based on its structural similarity. An investigation of a method to obtain 1,3-substituted cuneanes by...
7.
Sato Y, Hishinuma E, Yamazaki S, Ueda A, Kumondai M, Saito S, et al.
Drug Metab Dispos
. 2023 Sep;
51(12):1561-1568.
PMID: 37775333
Cytochrome P450 4F2 (CYP4F2) is an enzyme that is involved in the metabolism of arachidonic acid (AA), vitamin E and K, and xenobiotics including drugs. polymorphism (rs2108622; c.1297G>A; p.Val433Met) has...
8.
Yamamoto R, Segawa R, Liu J, Isaji T, Gu J, Hiratsuka M, et al.
Biochim Biophys Acta Gen Subj
. 2023 Sep;
1867(11):130465.
PMID: 37748663
Background: Cytokine receptor-like factor 2 (CRLF2) is a subunit of the receptor for thymic stromal lymphopoietin (TSLP). A somatic mutation (insEIM) in the transmembrane domains of CRLF2 has been identified...
9.
Segawa R, Kyoda T, Yagisawa M, Muramatsu T, Hiratsuka M, Hirasawa N
Int Immunopharmacol
. 2023 Apr;
118:110127.
PMID: 37030118
Atopic dermatitis (AD) is an allergic skin disease, triggered by excessive type 2 immune reactions. Thymic stromal lymphopoietin (TSLP) is an epithelial-derived cytokine that induces type 2 immune response through...
10.
Wang Y, Segawa R, Weng Y, Nakai K, Ohashi K, Hiratsuka M, et al.
J Transl Autoimmun
. 2023 Jan;
6:100186.
PMID: 36684807
Background: Thymic stromal lymphopoietin (TSLP) has been shown to be able to amplify Tregs. Thus, TSLP induction has the potential to induce endogenous Tregs and control autoimmunity. In the previous...