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Hikaru Suenaga

Explore the profile of Hikaru Suenaga including associated specialties, affiliations and a list of published articles. Areas
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Articles 60
Citations 437
Followers 0
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Recent Articles
1.
Hashimoto T, Suenaga H, Shin-Ya K
Chembiochem . 2024 Dec; 26(3):e202400765. PMID: 39741118
Engineering of nonribosomal peptide synthetases (NRPSs) could transform the production of bioactive natural product derivatives. A number of recent reports have described the engineering of NRPSs without marked reductions in...
2.
Kudo K, Nishimura T, Miyako K, Suenaga H, Shin-Ya K
J Antibiot (Tokyo) . 2024 Dec; 78(2):126-130. PMID: 39627321
A new derivative of cannabigerolic acid, designated as iso-cannabigerolic acid (iso-CBGA), a member of the cannabinoid family, and its precursor iso-olivetolic acid (iso-OA) were discovered from the culture of the...
3.
Koshiguchi M, Yonezawa N, Hatano Y, Suenaga H, Yamagata K, Kobayashi S
Sci Rep . 2024 Sep; 14(1):20327. PMID: 39223177
In female eutherian mammal development, X-chromosome inactivation (XCI) of one of the two X chromosomes is initiated early. Understanding the relationship between the initiation of XCI and cell fate is...
4.
Nishimura T, Kudo K, Izumikawa M, Kozone I, Hashimoto J, Kagaya N, et al.
Chem Pharm Bull (Tokyo) . 2024 May; 72(5):475-479. PMID: 38749722
Heterologous expression of natural compound biosynthetic gene clusters (BGCs) is a robust approach for not only revealing the biosynthetic mechanisms leading to the compounds, but also for discovering new products...
5.
Song X, Nihashi Y, Imai Y, Mori N, Kagaya N, Suenaga H, et al.
Int J Mol Sci . 2024 Apr; 25(7). PMID: 38612551
Pancreatic ductal adenocarcinoma (PDAC) is a solid-tumor malignancy. To enhance the treatment landscape of PDAC, a 3D model optimized for rigorous drug screening is essential. Within the PDAC tumor microenvironment,...
6.
Kudo K, Nishimura T, Izumikawa M, Kozone I, Hashimoto J, Fujie M, et al.
J Antibiot (Tokyo) . 2024 Mar; 77(5):288-298. PMID: 38438499
The biosynthetic gene clusters (BGCs) for the macrocyclic lactone-based polyketide compounds are extremely large-sized because the polyketide synthases that generate the polyketide chains of the basic backbone are of very...
7.
Hashimoto T, Suenaga H, Amagai K, Hashimoto J, Kozone I, Takahashi S, et al.
Angew Chem Int Ed Engl . 2024 Jan; 63(10):e202317805. PMID: 38238265
Heterotrimeric G proteins are key mediators in the signaling of G protein-coupled receptors (GPCR) that are involved in a plethora of important physiological processes and thus major targets of pharmaceutical...
8.
Suzuki S, Saito S, Narushima Y, Kodani S, Kagaya N, Suenaga H, et al.
J Antibiot (Tokyo) . 2023 Nov; 77(1):30-38. PMID: 37938761
We screened a library of microbial extracts and compounds library using our constructed assay cells and found pulicatins F (1) and G (2), and cyclopiazonic acid (CPA) (3) as Notch...
9.
Fujihara H, Hirose J, Suenaga H
Front Microbiol . 2023 Jun; 14:1168246. PMID: 37350784
A variety of bacteria in the environment can utilize xenobiotic compounds as a source of carbon and energy. The bacterial strains degrading xenobiotics are suitable models to investigate the adaptation...
10.
Hayashi T, Hase D, Suenaga H, Ohsawa Y
Sci Rep . 2022 Oct; 12(1):18092. PMID: 36302820
This study focused on human contact behavior with objects and discussed countermeasures during the COVID-19 pandemic across 15 location types. Reducing contact with objects and disinfecting items can be implemented...