Noriaki Shimizu
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Explore the profile of Noriaki Shimizu including associated specialties, affiliations and a list of published articles.
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69
Citations
1609
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Recent Articles
1.
Sano H, Kratz A, Nishino T, Imamura H, Yoshida Y, Shimizu N, et al.
Sci Rep
. 2023 Jul;
13(1):11765.
PMID: 37474783
NMN is the direct precursor of nicotinamide adenine dinucleotide (NAD+) and is considered as a key factor for increasing NAD+ levels and mitochondrial activity in cells. In this study, based...
2.
Tanabe K, Najima Y, Inokuchi T, Endo M, Nishio Y, Sadato D, et al.
Rinsho Ketsueki
. 2022 Aug;
63(7):746-752.
PMID: 35922942
A 22-year-old man with a history of mediastinal germ cell tumor, which was diagnosed at age 20 and remained disease-free after chemotherapy, was diagnosed with acute myeloid leukemia (AML) M2...
3.
Shimizu N
Genes (Basel)
. 2021 Oct;
12(10).
PMID: 34680928
Oncogene amplification is closely linked to the pathogenesis of a broad spectrum of human malignant tumors. The amplified genes localize either to the extrachromosomal circular DNA, which has been referred...
4.
Taniguchi R, Utani K, Thakur B, Ishine K, Aladjem M, Shimizu N
J Biol Chem
. 2021 Feb;
296:100356.
PMID: 33539925
Sirtuin 1 (SIRT1) is a protein deacetylase that maintains genome stability by preventing the activation of latent replication origins. Amplified genes in cancer cells localize on either extrachromosomal double minutes...
5.
Ogaki Y, Fukuma M, Shimizu N
PLoS One
. 2020 Jun;
15(6):e0235127.
PMID: 32579599
Repeat-induced gene silencing (RIGS) establishes the centromere structure, prevents the spread of transposons and silences transgenes, thereby limiting recombinant protein production. We previously isolated a sequence (B-3-31) that alleviates RIGS...
6.
Ohira T, Miyauchi K, Uno N, Shimizu N, Kazuki Y, Oshimura M, et al.
Sci Rep
. 2019 Nov;
9(1):16954.
PMID: 31740706
Gene amplification methods play a crucial role in establishment of cells that produce high levels of recombinant protein. However, the stability of such cell lines and the level of recombinant...
7.
Oobatake Y, Shimizu N
Genes Chromosomes Cancer
. 2019 Oct;
59(3):133-143.
PMID: 31569279
Gene amplification plays a pivotal role in malignant transformation. Amplified genes often reside on extrachromosomal double minutes (DMs). Low-dose hydroxyurea induces DM aggregation in the nucleus which, in turn, generates...
8.
Asoshina M, Myo G, Tada N, Tajino K, Shimizu N
Nucleic Acids Res
. 2019 May;
47(11):5998-6006.
PMID: 31062017
A plasmid with a replication initiation region (IR) and a matrix attachment region (MAR) initiates gene amplification in mammalian cells at a random chromosomal location. A mouse artificial chromosome (MAC)...
9.
Shimizu N, Kapoor R, Naniwa S, Sakamaru N, Yamada T, Yamamura Y, et al.
BMC Mol Cell Biol
. 2019 May;
20(1):2.
PMID: 31041889
Background: Extrachromosomal acentric double minutes (DMs) contribute to human malignancy by carrying amplified oncogenes. Recent cancer genomics revealed that the pulverization of defined chromosome arms (chromothripsis) may generate DMs, however,...
10.
Matsuhashi T, Endo J, Katsumata Y, Yamamoto T, Shimizu N, Yoshikawa N, et al.
J Mol Cell Cardiol
. 2019 Apr;
130:122-130.
PMID: 30946837
Glucocorticoid receptor (GR) is abundantly expressed in cardiomyocytes. However, the role of GR in regulating cardiac hypertrophy and heart failure in response to pressure overload remains unclear. Cardiomyocyte-specific GR knockout...