Norbert Kirchner
Overview
Explore the profile of Norbert Kirchner including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
66
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Recent Articles
1.
Kirchner N, Cano-Prieto C, Schulz-Fincke A, Gutschow M, Ortlieb N, Moschny J, et al.
J Nat Prod
. 2020 Dec;
84(1):101-109.
PMID: 33382250
Genome mining of the bacterial strains sp. SH-C52 and DSM 11579 showed that both strains contained a highly similar gene cluster encoding an octamodular nonribosomal peptide synthetase (NRPS) system which...
2.
Kirchner N, Cano-Prieto C, van der Voort M, Raaijmakers J, Gross H
Microbiol Resour Announc
. 2020 May;
9(21).
PMID: 32439665
DSM 11579 is known to be a producer of the lipopeptides brabantamide and thanamycin. Its draft genome gives insight into the complete secondary metabolite production capacity of the strain and...
3.
Schafhauser T, Jahn L, Kirchner N, Kulik A, Flor L, Lang A, et al.
Proc Natl Acad Sci U S A
. 2019 Dec;
116(52):26909-26917.
PMID: 31811021
Medicinal plants are a prolific source of natural products with remarkable chemical and biological properties, many of which have considerable remedial benefits. Numerous medicinal plants are suffering from wildcrafting, and...
4.
Leipoldt F, Santos-Aberturas J, Stegmann D, Wolf F, Kulik A, Lacret R, et al.
Nat Commun
. 2017 Dec;
8(1):1965.
PMID: 29213087
Metalloproteinase inhibitors often feature hydroxamate moieties to facilitate the chelation of metal ions in the catalytic center of target enzymes. Actinonin and matlystatins are potent metalloproteinase inhibitors that comprise rare...
5.
Schafhauser T, Kirchner N, Kulik A, Huijbers M, Flor L, Caradec T, et al.
Environ Microbiol
. 2016 Mar;
18(11):3728-3741.
PMID: 26954535
Talaromyces islandicus ('Penicillium islandicum') is a widespread foodborne mold that produces numerous secondary metabolites, among them potent mycotoxins belonging to different chemical classes. A notable metabolite is the hepatotoxic and...
6.
Spohn M, Kirchner N, Kulik A, Jochim A, Wolf F, Muenzer P, et al.
Antimicrob Agents Chemother
. 2014 Aug;
58(10):6185-96.
PMID: 25114137
The emergence of antibiotic-resistant pathogenic bacteria within the last decades is one reason for the urgent need for new antibacterial agents. A strategy to discover new anti-infective compounds is the...