Nonhlanhla N Mkhize
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Explore the profile of Nonhlanhla N Mkhize including associated specialties, affiliations and a list of published articles.
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38
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788
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Recent Articles
11.
Moyo-Gwete T, Madzivhandila M, Mkhize N, Kgagudi P, Ayres F, Lambson B, et al.
J Virol
. 2022 Jul;
96(15):e0055822.
PMID: 35867572
As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to evolve, several variants of concern (VOCs) have arisen which are defined by multiple mutations in their spike proteins. These VOCs...
12.
Mahomed S, Garrett N, Capparelli E, Osman F, Harkoo I, Yende-Zuma N, et al.
J Infect Dis
. 2022 Feb;
226(3):510-520.
PMID: 35134995
Background: Effective, long-acting prevention approaches are needed to reduce human immunodeficiency virus (HIV) incidence. We evaluated the safety and pharmacokinetics of VRC07-523LS and PGT121 administered subcutaneously alone and in combination...
13.
Huang Y, Zhang L, Eaton A, Mkhize N, Carpp L, Rudnicki E, et al.
Hum Vaccin Immunother
. 2021 Jul;
18(1):1908030.
PMID: 34213402
VRC01 is being evaluated in the AMP efficacy trials, the first assessment of a passively administered broadly neutralizing monoclonal antibody (bnAb) for HIV-1 prevention. A key analysis will assess serum...
14.
Dabee S, Mkhize N, Jaspan H, Lewis D, Gumbi P, Passmore J
AIDS Res Hum Retroviruses
. 2020 Jun;
36(10):821-830.
PMID: 32524856
Antiretroviral therapy (ART) has significantly improved the quality of life of HIV-infected individuals: reducing plasma viremia, restoring CD4 T cell numbers, and correcting imbalances in blood memory T cell subsets....
15.
Moodie Z, Walsh S, Laher F, Maganga L, Herce M, Naidoo S, et al.
PLoS Med
. 2020 May;
17(5):e1003117.
PMID: 32442195
Background: DNA plasmids promise a pragmatic alternative to viral vectors for prime-boost HIV-1 vaccines. We evaluated DNA plasmid versus canarypox virus (ALVAC) primes in 2 randomized, double-blind, placebo-controlled trials in...
16.
Laher F, Moodie Z, Cohen K, Grunenberg N, Bekker L, Allen M, et al.
PLoS Med
. 2020 Feb;
17(2):e1003038.
PMID: 32092060
Background: HVTN 100 evaluated the safety and immunogenicity of an HIV subtype C pox-protein vaccine regimen, investigating a 12-month booster to extend vaccine-induced immune responses. Methods And Findings: A phase...
17.
Ditse Z, Mkhize N, Yin M, Keefer M, Montefiori D, Tomaras G, et al.
mSphere
. 2020 Jan;
5(1).
PMID: 31996422
Analysis of breakthrough HIV-1 infections could elucidate whether prior vaccination primes relevant immune responses. Here, we measured HIV-specific antibody responses in 14 South African volunteers who acquired HIV infection after...
18.
Richardson S, Lambson B, Crowley A, Bashirova A, Scheepers C, Garrett N, et al.
PLoS Pathog
. 2019 Dec;
15(12):e1008064.
PMID: 31841557
Broadly neutralizing antibodies (bNAbs) protect against HIV infection in non-human primates and their efficacy may be enhanced through interaction with Fc receptors on immune cells. Antibody isotype is a modulator...
19.
Gray C, OHagan K, Lorenzo-Redondo R, Olivier A, Amu S, Chigorimbo-Murefu N, et al.
Mucosal Immunol
. 2019 Oct;
13(1):118-127.
PMID: 31619762
We compared outer and inner foreskin tissue from adolescent males undergoing medical male circumcision to better understand signals that increase HIV target cell availability in the foreskin. We measured chemokine...
20.
Gray G, Huang Y, Grunenberg N, Laher F, Roux S, Andersen-Nissen E, et al.
Sci Transl Med
. 2019 Sep;
11(510).
PMID: 31534016
One of the most successful HIV vaccines to date, the RV144 vaccine tested in Thailand, demonstrated correlates of protection including cross-clade V1V2 immunoglobulin G (IgG) breadth, Env-specific CD4 T cell...