Noel G McElvaney
Overview
Explore the profile of Noel G McElvaney including associated specialties, affiliations and a list of published articles.
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224
Citations
6603
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Recent Articles
1.
Herron M, Roche S, Fraughen D, Heeney R, Kanchi L, Leacy E, et al.
Thorax
. 2024 Nov;
80(1):24-31.
PMID: 39586664
Background: Bronchoalveolar lavage (BAL) is essential in determining the efficacy of novel therapies in alpha-1 antitrypsin deficiency (AATD). These require initial proof-of-concept demonstration that treatment administration increases alpha-1 antitrypsin (AAT)...
2.
Fromme M, Payance A, Mandorfer M, Thorhauge K, Pons M, Miravitlles M, et al.
Gastroenterology
. 2024 Oct;
168(2):367-381.
PMID: 39414159
Background & Aims: Homozygous Pi∗Z mutation in alpha-1 antitrypsin (Pi∗ZZ genotype) predisposes to pulmonary loss-of-function and hepatic gain-of-function injury. To facilitate selection into clinical trials typically targeting only 1 organ,...
3.
Murphy M, Zieger M, Henry M, Meleady P, Mueller C, McElvaney N, et al.
Am J Physiol Lung Cell Mol Physiol
. 2024 Aug;
327(4):L600-L606.
PMID: 39137524
Elastin is an extracellular matrix protein (ECM) that supports elasticity of the lung, and in patients with chronic obstructive pulmonary disease (COPD) and emphysema, the structural changes that reduce the...
4.
Harvey B, McElvaney N
Biol Sex Differ
. 2024 Jul;
15(1):56.
PMID: 39026347
Biological sex differences exist for many airway diseases in which females have either worse or better health outcomes. Inflammatory airway diseases such as cystic fibrosis (CF) and asthma display a...
5.
Murphy M, Hunt D, Herron M, McDonnell J, Alshuhoumi R, McGarvey L, et al.
J Immunol
. 2024 May;
213(1):75-85.
PMID: 38758115
In chronic obstructive pulmonary disease (COPD), inflammation gives rise to protease-mediated degradation of the key extracellular matrix protein, elastin, which causes irreversible loss of pulmonary function. Intervention against proteolysis has...
6.
Rocamora F, Schoffelen S, Arnsdorf J, Toth E, Abdul Y, Cleveland 4th T, et al.
bioRxiv
. 2024 Apr;
PMID: 38585818
Alpha-1-antitrypsin (A1AT) is a multifunctional, clinically important, high value therapeutic glycoprotein that can be used for the treatment of many diseases such as alpha-1-antitrypsin deficiency, diabetes, graft-versus-host-disease, cystic fibrosis and...
7.
Maher S, Ryan S, OBrien C, Fraughen D, Spooner M, McElvaney N
Ir J Med Sci
. 2024 Mar;
193(4):2091-2096.
PMID: 38478182
Background: Remediation of underperforming students is recognised as an important tool in medical education; however, there is no universally agreed approach. Aims: This study aimed to evaluate the effectiveness of...
8.
Gogoi D, Yu H, Casey M, Baird R, Yusuf A, Forde L, et al.
Thorax
. 2024 Feb;
79(9):822-833.
PMID: 38418195
Introduction: Altered complement component 3 (C3) activation in patients with alpha-1 antitrypsin (AAT) deficiency (AATD) has been reported. To understand the potential impact on course of inflammation, the aim of...
9.
Fraughen D, Ghosh A, Carroll T, McElvaney N
Am J Respir Crit Care Med
. 2024 Jan;
209(8):1034-1035.
PMID: 38237155
No abstract available.
10.
Brami I, Zuckerman T, Ram R, Avni B, Peretz G, Ostrovsky D, et al.
Int J Mol Sci
. 2024 Jan;
25(1).
PMID: 38203593
α1-Antitrypsin (AAT), an acute-phase reactant not unsimilar to C-reactive protein (CRP), is a serine protease inhibitor that harbors tissue-protective and immunomodulatory attributes. Its concentrations appropriately increase during conditions of extensive...