Cedric Gunaratnam
Overview
Explore the profile of Cedric Gunaratnam including associated specialties, affiliations and a list of published articles.
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30
Citations
1077
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Recent Articles
1.
Herron M, Roche S, Fraughen D, Heeney R, Kanchi L, Leacy E, et al.
Thorax
. 2024 Nov;
80(1):24-31.
PMID: 39586664
Background: Bronchoalveolar lavage (BAL) is essential in determining the efficacy of novel therapies in alpha-1 antitrypsin deficiency (AATD). These require initial proof-of-concept demonstration that treatment administration increases alpha-1 antitrypsin (AAT)...
2.
McElvaney O, Cleary B, Fraughen D, Kelly G, McElvaney O, Murphy M, et al.
Chronic Obstr Pulm Dis
. 2023 Sep;
11(1):3-12.
PMID: 37676644
Background: Patients with alpha-1 antitrypsin deficiency (AATD) exhibit dysregulated inflammatory responses and a predilection for autoimmunity. While the adverse event (AE) profiles of COVID-19 vaccines in several chronic inflammatory conditions...
3.
Fraughen D, Ghosh A, Hobbs B, Funk G, Meischl T, Clarenbach C, et al.
Am J Respir Crit Care Med
. 2023 Aug;
208(9):964-974.
PMID: 37624745
Intravenous plasma-purified alpha-1 antitrypsin (IV-AAT) has been used as therapy for alpha-1 antitrypsin deficiency (AATD) since 1987. Previous trials (RAPID and RAPID-OLE) demonstrated efficacy in preserving computed tomography of lung...
4.
Casey M, Gabillard-Lefort C, McElvaney O, McElvaney O, Carroll T, Heeney R, et al.
Thorax
. 2023 May;
78(8):835-839.
PMID: 37208188
Treatment with elexacaftor/tezacaftor/ivacaftor (ETI) has been shown to improve lung function in people with cystic fibrosis (PWCF). However, its biological effects remain incompletely understood. Here we describe alterations in pulmonary...
5.
McElvaney O, Cleary B, Fraughen D, Kelly G, Murphy M, McElvaney O, et al.
Chronic Obstr Pulm Dis
. 2022 Apr;
9(2):266-273.
PMID: 35403416
Patients with severe alpha-1 antitrypsin deficiency (AATD) are at increased risk for the development of chronic obstructive pulmonary disease (COPD), particularly if they smoke. This, coupled with their predilection for...
6.
Gabillard-Lefort C, Casey M, Glasgow A, Boland F, Kerr O, Marron E, et al.
Am J Respir Crit Care Med
. 2022 Jan;
205(7):783-794.
PMID: 35021019
Cystic fibrosis (CF) is caused by mutations in the CFTR (CF transmembrane conductance regulator) gene and is characterized by sustained inflammation. ATP triggers IL-1β secretion via P2X7R (P2X7 receptor) and...
7.
Hayes E, Murphy M, Pohl K, Browne N, McQuillan K, Saw L, et al.
Front Immunol
. 2021 Jan;
11:600033.
PMID: 33391268
Studies have endeavored to understand the cause for impaired antimicrobial killing by neutrophils of people with cystic fibrosis (PWCF). The aim of this study was to focus on the bacterial...
8.
McElvaney O, OConnor E, McEvoy N, Fraughan D, Clarke J, McElvaney O, et al.
J Cyst Fibros
. 2020 Dec;
20(1):31-35.
PMID: 33288475
Background: The clinical course of severe COVID-19 in cystic fibrosis (CF) is incompletely understood. We describe the use of alpha-1 antitrypsin (AAT) as a salvage therapy in a critically unwell...
9.
Ryan D, Toomey S, Madden S, Casey M, Breathnach O, Morris P, et al.
Thorax
. 2020 Oct;
76(1):86-88.
PMID: 33097604
False negatives from nasopharyngeal swabs (NPS) using reverse transcriptase PCR (RT-PCR) in SARS-CoV-2 are high. Exhaled breath condensate (EBC) contains lower respiratory droplets that may improve detection. We performed EBC...
10.
OBrien H, Tracey M, Ottewill C, OBrien M, Morgan R, Costello R, et al.
Ir J Med Sci
. 2020 Sep;
190(2):461-468.
PMID: 32894436
Background: In January 2020, the WHO declared the SARS-CoV-2 outbreak a public health emergency; by March 11, a pandemic was declared. To date in Ireland, over 3300 patients have been...