Noel A Warfel
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Explore the profile of Noel A Warfel including associated specialties, affiliations and a list of published articles.
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35
Citations
981
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Recent Articles
1.
Clements A, Casillas A, Flores C, Liou H, Toth R, Chauhan S, et al.
Cancer Immunol Res
. 2025 Feb;
PMID: 39982419
Immune checkpoint inhibitors (ICIs) have changed the treatment paradigm for many cancers but have not shown benefit in prostate cancer (PCa). Chronic inflammation contributes to the immunosuppressive prostate tumor microenvironment...
2.
Clements A, Casillas A, Flores C, Liou H, Toth R, Chauhan S, et al.
bioRxiv
. 2024 Nov;
PMID: 39484473
Immunotherapy has changed the treatment paradigm for many types of cancer, but immune checkpoint inhibitors (ICIs) have not shown benefit in prostate cancer (PCa). Chronic inflammation contributes to the immunosuppressive...
3.
Tang H, Gupta A, Morrisroe S, Bao C, Schwantes-An T, Gupta G, et al.
Circulation
. 2024 May;
150(4):302-316.
PMID: 38695173
Background: The ubiquitin-proteasome system regulates protein degradation and the development of pulmonary arterial hypertension (PAH), but knowledge about the role of deubiquitinating enzymes in this process is limited. UCHL1 (ubiquitin...
4.
Chauhan S, Casillas A, Vizzerra A, Liou H, Clements A, Flores C, et al.
Oncogene
. 2023 Dec;
43(6):406-419.
PMID: 38097734
Lipid droplets (LDs) are dynamic organelles with a neutral lipid core surrounded by a phospholipid monolayer. Solid tumors exhibit LD accumulation, and it is believed that LDs promote cell survival...
5.
Torres-Ayuso P, Katerji M, Mehlich D, Lookingbill S, Sabbasani V, Liou H, et al.
Cell Chem Biol
. 2023 Nov;
31(2):326-337.e11.
PMID: 38016478
PIM kinases have important pro-tumorigenic roles and mediate several oncogenic traits, including cell proliferation, survival, and chemotherapeutic resistance. As a result, multiple PIM inhibitors have been pursued as investigational new...
6.
Jensen C, Clements A, Liou H, Ball L, Bethard J, Langlais P, et al.
J Cell Biol
. 2023 Apr;
222(6).
PMID: 37042842
Distinguishing key factors that drive the switch from indolent to invasive disease will make a significant impact on guiding the treatment of prostate cancer (PCa) patients. Here, we identify a...
7.
Marr K, Ignatenko N, Warfel N, Batai K, Cress A, Pollock G, et al.
Front Oncol
. 2023 Feb;
12:1083150.
PMID: 36727054
The advent of perpetuating living organoids derived from patient tissue is a promising avenue for cancer research but is limited by difficulties with precise characterization. In this brief communication, we...
8.
Clements A, Warfel N
Cells
. 2022 Nov;
11(22).
PMID: 36429128
The Proviral Integration site for Moloney murine leukemia virus (PIM) kinases is a family of serine/threonine kinases that regulates numerous signaling networks that promote cell growth, proliferation, and survival. PIM...
9.
Hill S, Padilla-Rodriguez M, Clements A, Sweetland J, Parker S, Warfel N, et al.
STAR Protoc
. 2022 Jul;
3(3):101516.
PMID: 35780429
We describe a three-dimensional (3D) in vitro assay for quantifying cancer cell invasion into a 3D microenvironment with defined biochemical and biophysical properties. Researchers can quantify invasion dynamics (e.g., cell...
10.
Ryniawec J, Coope M, Loertscher E, Bageerathan V, De Oliveira Pessoa D, Warfel N, et al.
Diagnostics (Basel)
. 2022 Mar;
12(3).
PMID: 35328229
The microenvironment of solid tumors is dynamic and frequently contains pockets of low oxygen levels (hypoxia) surrounded by oxygenated tissue. Indeed, a compromised vasculature is a hallmark of the tumor...