Nobuko Kakiuchi
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Explore the profile of Nobuko Kakiuchi including associated specialties, affiliations and a list of published articles.
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25
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159
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Recent Articles
1.
Jo M, Nakamura N, Kakiuchi N, Komatsu K, Qui M, Shimotohno K, et al.
J Nat Med
. 2018 Feb;
60(3):217-224.
PMID: 29435894
For the purpose of developing novel anti-hepatitis C virus (HCV) agents from natural resources, 93 Yunnan crude drugs were screened for their inhibitory effects on RNA-dependent RNA polymerase (RdRp) of...
2.
Kakiuchi N
Yakugaku Zasshi
. 2017 Oct;
137(10):1193-1200.
PMID: 28966259
Although Kampo medicine is now fully integrated into the modern Japanese healthcare system, most Kampo formulations depend on imported crude drugs from limited foreign areas. To prepare for possible shortages...
3.
Ohtsuka I, Hada N, Kanemaru M, Fujii T, Atsumi T, Kakiuchi N
Carbohydr Res
. 2015 Feb;
404:9-16.
PMID: 25659120
The glycosphingolipid neurosporaside (α-D-Glcp-(1 → 2)-β-D-Galp-(1 → 6)-β-D-Galp-(1 → 6)-β-D-Galp-(1 →)-Cer) occurs in Neurospora crassa. We attempted to synthesize neurosporaside by block synthesis (route A) and linear synthesis (route B)....
4.
Kakiuchi N, Atsumi T, Higuchi M, Kamikawa S, Miyako H, Wakita Y, et al.
J Nat Med
. 2014 Sep;
69(1):154-64.
PMID: 25199501
Aconite tuber is a representative crude drug for warming the body internally in Japanese Kampo medicine and Chinese traditional medicine. The crude drug is used in major prescriptions for the...
5.
Ohtsuka I, Sadakane Y, Hada N, Higuchi M, Atsumi T, Kakiuchi N
Bioorg Med Chem
. 2014 Jul;
22(15):3829-37.
PMID: 25012569
Photoaffinity labeling technology is a highly efficient method for cloning carbohydrate-binding proteins. When the carbohydrate probes are synthesized according to conventional methods, however, the reducing terminus of the sugar is...
6.
Kakiuchi N, Iwaki N, Mikage M, Xiao H, Wang Z, Hattori M
J Nat Med
. 2013 May;
68(1):206-10.
PMID: 23653334
Aiming to examine whether the genetic background of the crude drugs derived from four Yunnanese Swertia plants and their chemical constituent profiles correlate, we analyzed the nucleotide sequences of their...
7.
Kobira S, Atsumi T, Kakiuchi N, Mikage M
J Nat Med
. 2011 Dec;
66(3):493-9.
PMID: 22127530
Poria, a dried sclerotium of Wolfiporia cocos Ryvarden et Gilbertson (Polyporaceae) has been used as a crude drug in both Chinese and Japanese (Kampo) traditional medicines. Recently, cultivated products of...
8.
Doui M, Ando H, Goi C, Kakiuchi N, Mikage M
Yakushigaku Zasshi
. 2011 Jun;
45(2):106-11.
PMID: 21661236
In traditional Chinese medicine, it has long been thought that the medicinal effect of a crude drug can be modified by combination with other crude drugs. One well-known example is...
9.
Ohtsuka I, Sadakane Y, Higuchi M, Hada N, Hada J, Kakiuchi N, et al.
Bioorg Med Chem
. 2011 Jan;
19(2):894-9.
PMID: 21211984
Because carbohydrates and proteins bind with such low affinity, the nature of their interactions is not clear. Photoaffinity labeling with diazirin groups is useful for elucidating the roles of carbohydrates...
10.
Kawasaki R, Motoya W, Atsumi T, Mouri C, Kakiuchi N, Mikage M
J Nat Med
. 2010 Oct;
65(1):111-5.
PMID: 20886302
Processed root of aconite, Aconitum carmichaeli Debeaux--known as bushi in Japan--is indispensable for treating diseases among elderly persons in Japanese and Chinese traditional medicine. Its active component is bushi diester...