Inhibitory Effect of Yunnan Traditional Medicines on Hepatitis C Viral Polymerase

Overview

Journal J Nat Med

Publisher Springer

Date 2018 Feb 14

PMID 29435894

Citations 2

Authors

Michiko Jo

Norio Nakamura

Nobuko Kakiuchi

Katsuko Komatsu

Ming-Hua Qui

Kumiko Shimotohno

Kunitada Shimotohno

Masao Hattori

Affiliations

Soon will be listed here.

Abstract

For the purpose of developing novel anti-hepatitis C virus (HCV) agents from natural resources, 93 Yunnan crude drugs were screened for their inhibitory effects on RNA-dependent RNA polymerase (RdRp) of HCV. Although 71 methanol extracts and 50 water extracts inhibited HCV-RdRp by more than 50% at a concentration of 50 μg/ml, the majority of them contained a high percentage of tannins. However, methanol extracts of Plumbago zeylanica (branch), Maytenus fookerii (leaf) and Huashidancha (Y61, branch and leaf), and water extracts of Potentilla griffithii (whole plant) and Salvia yunnanensis (underground part), having IC values of less than 10 μg/ml, showed less than 10% tannin content. In addition, from a methanol extract of Tripterygium hypoglaucum (root bark), demethylzeylasteral was isolated as a strongly inhibitory substance against HCV-RdRp.

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