Nobuko Futaki
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Explore the profile of Nobuko Futaki including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
122
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Recent Articles
1.
Sugimoto M, Toda Y, Hori M, Mitani A, Ichihara T, Sekine S, et al.
Drug Dev Res
. 2016 Jan;
77(1):20-8.
PMID: 26763139
Preclinical Research This article describes the properties of a novel topical NSAID (Nonsteroidal anti-inflammatory drug) patch, SFPP (S(+)-flurbiprofen plaster), containing the potent cyclooxygenase (COX) inhibitor, S(+)-flurbiprofen (SFP). The present studies...
2.
Sugimoto M, Futaki N, Harada M, Kaku S
Bone
. 2012 Oct;
52(1):181-8.
PMID: 23041510
Eldecalcitol (ELD), a 2β-hydroxypropyloxy derivative of 1α,25 (OH) 2D3, inhibits bone resorption more potently than alfacalcidol (ALF) while maintaining osteoblastic function in an ovariectomized (OVX) osteoporosis rat model. Alendronate (ALN),...
3.
Hashimoto Y, Takaoka A, Sugimoto M, Honma Y, Sakurai T, Futaki N, et al.
Exp Dermatol
. 2011 Jul;
20(10):820-5.
PMID: 21771100
Atopic dermatitis (AD) is related to immunoglobulin E (IgE) production, and a type-1 and type-2 helper T cell (Th1/Th2) imbalance has been hypothesized as the aetiology. While itching and scratching...
4.
Yoshimura H, Sekine S, Adachi H, Uematsu Y, Mitani A, Futaki N, et al.
Protein Expr Purif
. 2011 Jun;
80(1):41-6.
PMID: 21645621
We report the expression of a high level of human cyclooxygenase-1 (hCOX-1) in mammalian cells using a novel gene amplification method known as the IR/MAR gene amplification system. IR/MAR-plasmids contain...
5.
Futaki N, Harada M, Sugimoto M, Hashimoto Y, Honma Y, Arai I, et al.
J Pharm Pharmacol
. 2009 May;
61(5):607-14.
PMID: 19405999
Objectives: Lornoxicam is a non-selective cyclooxygenase inhibitor that exhibits strong analgesic and anti-inflammatory effects but a weak antipyretic effect in rat models. Our aim was to investigate the mechanism of...
6.
Ohta H, Ishizaka T, Tatsuzuki M, Yoshinaga M, Iida I, Yamaguchi T, et al.
Bioorg Med Chem
. 2007 Nov;
16(3):1111-24.
PMID: 18006322
In this study, a novel series of CB(2) receptor agonist imine derivatives, 1-6, was synthesized and evaluated for activity against the CB(2) receptor. In a previous paper we reported the...
7.
Inoue T, Sugimoto M, Sakurai T, Saito R, Futaki N, Hashimoto Y, et al.
J Gene Med
. 2007 Aug;
9(11):994-1001.
PMID: 17703497
Background: RNA interference (RNAi) is rapidly becoming a major tool that is revolutionizing research in the bioscience and biomedical fields. To apply the RNAi technique in vivo, it is crucial...
8.
Takaoka A, Arai I, Sugimoto M, Futaki N, Sakurai T, Honma Y, et al.
Exp Dermatol
. 2007 Mar;
16(4):331-9.
PMID: 17359340
NC/Nga mice are known to develop scratching dermatitis akin to atopic dermatitis, under conventional (Conv), but not under the specific-pathogen-free (SPF) condition. In this study, we examined the effects of...
9.
Sugimoto M, Arai I, Futaki N, Hashimoto Y, Sakurai T, Honma Y, et al.
Eur J Pharmacol
. 2007 Mar;
564(1-3):196-203.
PMID: 17328887
TS-022 is a prostanoid DP(1) receptor agonist, originally developed as a novel anti-pruritic drug for atopic dermatitis. The drug has been shown to suppress scratching and improve the skin inflammation...
10.
Sugimoto M, Arai I, Futaki N, Honma Y, Sakurai T, Hashimoto Y, et al.
Prostaglandins Leukot Essent Fatty Acids
. 2007 Jan;
76(2):93-101.
PMID: 17250998
In atopic dermatitis, scratching of the skin as a reaction to itching causes injury to the skin, which, in turn, further increases the itching resulting in the establishment of the...