Noaman M Hasan
Overview
Explore the profile of Noaman M Hasan including associated specialties, affiliations and a list of published articles.
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16
Citations
458
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Recent Articles
1.
MacDonald M, Hasan N, Ansari I, Longacre M, Kendrick M, Stoker S
Diabetes
. 2016 May;
65(7):2051-9.
PMID: 27207549
A mechanistic cause for Mauriac syndrome, a syndrome of growth failure and delayed puberty associated with massive liver enlargement from glycogen deposition in children with poorly controlled type 1 diabetes,...
2.
Hasan N, Longacre M, Stoker S, Kendrick M, MacDonald M
Mol Endocrinol
. 2015 Jan;
29(3):396-410.
PMID: 25594249
Pancreatic β-cells with severely knocked down cytosolic malic enzyme (ME1) and mitochondrial NAD(P) malic enzyme (ME2) show normal insulin secretion. The mitochondrial NADP malic enzyme (ME3) is very low in...
3.
MacDonald M, Brown L, Longacre M, Stoker S, Kendrick M, Hasan N
Biochim Biophys Acta
. 2013 Jul;
1830(11):5104-11.
PMID: 23876293
Background: There are three isocitrate dehydrogenases (IDHs) in the pancreatic insulin cell; IDH1 (cytosolic) and IDH2 (mitochondrial) use NADP(H). IDH3 is mitochondrial, uses NAD(H) and was believed to be the...
4.
MacDonald M, Hasan N, Dobrzyn A, Stoker S, Ntambi J, Liu X, et al.
Arch Biochem Biophys
. 2013 Jan;
532(1):23-31.
PMID: 23357280
We previously showed that knockdown of the anaplerotic enzyme pyruvate carboxylase in the INS-1 832/13 insulinoma cell line inhibited glucose-stimulated insulin release and glucose carbon incorporation into lipids. We now...
5.
MacDonald M, Longacre M, Stoker S, Kendrick M, Thonpho A, Brown L, et al.
J Biol Chem
. 2011 Apr;
286(21):18383-96.
PMID: 21454710
Anaplerosis, the net synthesis in mitochondria of citric acid cycle intermediates, and cataplerosis, their export to the cytosol, have been shown to be important for insulin secretion in rodent beta...
6.
Hasan N, Longacre M, Seed Ahmed M, Kendrick M, Gu H, Ostenson C, et al.
Arch Biochem Biophys
. 2010 May;
499(1-2):62-8.
PMID: 20460097
Succinyl-CoA:3-ketoacid-CoA transferase (SCOT) is a mitochondrial enzyme that catalyzes the reversible transfer of coenzyme-A from acetoacetyl-CoA to succinate to form acetoacetate and succinyl-CoA. mRNAs of SCOT and ATP citrate lyase...
7.
Hasan N, Kendrick M, Druckenbrod N, Huelsmeyer M, Warner T, MacDonald M
Diabetes Res Clin Pract
. 2010 Jan;
87(3):e29-32.
PMID: 20053475
Minor alleles of two SNPs in intron 9 of the NRP1 gene, which encodes neuropilin-1, were found to be associated with type 1 diabetes (T1D) in children. Neuropilin-1 peptides were...
8.
Brown L, Longacre M, Hasan N, Kendrick M, Stoker S, MacDonald M
J Biol Chem
. 2009 Oct;
284(51):35359-67.
PMID: 19858194
The cytosolic malic enzyme (ME1) has been suggested to augment insulin secretion via the malate-pyruvate and/or citrate-pyruvate shuttles, through the production of NADPH or other metabolites. We used selectable vectors...
9.
Hasan N, Longacre M, Stoker S, Boonsaen T, Jitrapakdee S, Kendrick M, et al.
J Biol Chem
. 2008 Aug;
283(42):28048-59.
PMID: 18697738
Anaplerosis, the synthesis of citric acid cycle intermediates, by pancreatic beta cell mitochondria has been proposed to be as important for insulin secretion as mitochondrial energy production. However, studies designed...
10.
MacDonald M, Hasan N, Longacre M
Biochim Biophys Acta
. 2008 Apr;
1780(7-8):966-72.
PMID: 18439432
We hypothesized that contrasting leucine with its non-metabolizable analog 2-aminobicyclo[2,2,1]heptane-2-carboxylic acid (BCH) might provide new information about metabolic pathways involved in insulin secretion. Both compounds stimulate insulin secretion by allosterically...