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Noam Levaot

Explore the profile of Noam Levaot including associated specialties, affiliations and a list of published articles. Areas
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Articles 19
Citations 324
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Recent Articles
1.
Zur Y, Katchkovsky S, Itzhar A, Abramovitch-Dahan C, Stepensky D, Papo N, et al.
Int J Biol Macromol . 2024 Oct; 282(Pt 2):136821. PMID: 39447795
Osteoporosis is a common, age-related disease caused by imbalanced bone remodeling. Current treatments either shut down bone resorption or robustly stimulate bone formation. Here, we describe a novel compound that...
2.
Katchkovsky S, Meiri R, Lacham-Hartman S, Orenstein Y, Levaot N, Papo N
FEBS Lett . 2024 Oct; 599(3):316-329. PMID: 39443289
The interaction of sclerostin (Scl) with the low-density lipoprotein receptor-related protein 4 (LRP4) leads to a marked reduction in bone formation by inhibiting the Wnt/β-catenin pathway. To characterize the Scl-LRP4...
3.
Drabkin M, Jean M, Noy Y, Halperin D, Yogev Y, Wormser O, et al.
J Med Genet . 2023 Jul; 61(2):117-124. PMID: 37399313
Background: Otosclerosis is a common cause of adult-onset progressive hearing loss, affecting 0.3%-0.4% of the population. It results from dysregulation of bone homeostasis in the otic capsule, most commonly leading...
4.
Meirow Y, Jovanovic M, Zur Y, Habib J, Colombo D, Twaik N, et al.
Bone Res . 2022 Apr; 10(1):36. PMID: 35396510
Elevated osteoclast (OC) activity is a major contributor to inflammatory bone loss (IBL) during chronic inflammatory diseases. However, the specific OC precursors (OCPs) responding to inflammatory cues and the underlying...
5.
Katchkovsky S, Chatterjee B, Abramovitch-Dahan C, Papo N, Levaot N
Cell Mol Life Sci . 2022 Jan; 79(2):113. PMID: 35099616
Induction of bone formation by Wnt ligands is inhibited when sclerostin (Scl), an osteocyte-produced antagonist, binds to its receptors, the low-density lipoprotein receptor-related proteins 5 or 6 (LRP5/6). Recently, it...
6.
Gabet Y, Neumann D, Levaot N, Elson A, Sims N
Front Cell Dev Biol . 2021 Nov; 9:769320. PMID: 34746157
No abstract available.
7.
Bar Droma E, Beck-Rosen G, Ilgiyaev A, Fruchtman Y, Abramovitch-Dahan C, Levaot N, et al.
J Oral Maxillofac Surg . 2020 Jul; 78(12):2226-2234. PMID: 32649899
Cherubism is a rare autosomal dominant disease whose severity ranges widely, from asymptomatic to life-threatening. Bilateral symmetrical painless expansion of the mandible and maxilla resulting in a typical appearance of...
8.
Felder S, Masasa H, Orenbuch A, Levaot N, Shachar Goldenberg M, Cohen S
Biomaterials . 2019 Mar; 205:11-22. PMID: 30901634
Implementing ovarian tissue engineering for the maturation of primordial follicles, the most abundant follicle population in the ovary, holds great potential for women fertility preservation. Here, we evaluated whether macroporous...
9.
Hirsch N, Eshel R, Bar Yaacov R, Shahar T, Shmulevich F, Dahan I, et al.
PLoS Genet . 2018 Oct; 14(10):e1007738. PMID: 30372441
The transcription factor TWIST1 plays a vital role in mesoderm development, particularly in limb and craniofacial formation. Accordingly, haploinsufficiency of TWIST1 can cause limb and craniofacial malformations as part of...
10.
Omar I, Guterman-Ram G, Rahat D, Tabach Y, Berger M, Levaot N
Sci Rep . 2018 Aug; 8(1):13005. PMID: 30158544
Osteoclasts are the bone resorbing cells that derive from myeloid progenitor cells. Although there have been recent advancements in the ability to identify osteoclast progenitors, very little is known about...