Niya Aleksieva
Overview
Explore the profile of Niya Aleksieva including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
7
Citations
236
Followers
0
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Recent Articles
1.
Ferreira-Gonzalez S, Man T, Esser H, Aird R, Kilpatrick A, Rodrigo-Torres D, et al.
Sci Transl Med
. 2022 Dec;
14(674):eabj4375.
PMID: 36475903
Liver transplantation is the only curative option for patients with end-stage liver disease. Despite improvements in surgical techniques, nonanastomotic strictures (characterized by the progressive loss of biliary tract architecture) continue...
2.
Minnis-Lyons S, Ferreira-Gonzalez S, Aleksieva N, Man T, Gadd V, Williams M, et al.
Sci Signal
. 2021 Jun;
14(688).
PMID: 34158399
In the adult liver, a population of facultative progenitor cells called biliary epithelial cells (BECs) proliferate and differentiate into cholangiocytes and hepatocytes after injury, thereby restoring liver function. In mammalian...
3.
Gadd V, Aleksieva N, Forbes S
Cell Stem Cell
. 2020 Sep;
27(4):557-573.
PMID: 32971004
Following injury, the liver's epithelial cells regenerate efficiently with rapid proliferation of hepatocytes and biliary cells. However, when proliferation of resident epithelial cells is impaired, alternative regeneration mechanisms can occur....
4.
Pastore N, Huynh T, Herz N, Calcagni A, Klisch T, Brunetti L, et al.
Nat Commun
. 2020 May;
11(1):2461.
PMID: 32424153
It is well established that pluripotent stem cells in fetal and postnatal liver (LPCs) can differentiate into both hepatocytes and cholangiocytes. However, the signaling pathways implicated in the differentiation of...
5.
Lewis P, Campana L, Aleksieva N, Cartwright J, MacKinnon A, ODuibhir E, et al.
J Hepatol
. 2020 Mar;
73(2):349-360.
PMID: 32169610
Background & Aim: Following acetaminophen (APAP) overdose, acute liver injury (ALI) can occur in patients that present too late for N-acetylcysteine treatment, potentially leading to acute liver failure, systemic inflammation,...
6.
Aloia L, McKie M, Vernaz G, Cordero-Espinoza L, Aleksieva N, van den Ameele J, et al.
Nat Cell Biol
. 2019 Nov;
21(11):1321-1333.
PMID: 31685987
Following severe or chronic liver injury, adult ductal cells (cholangiocytes) contribute to regeneration by restoring both hepatocytes and cholangiocytes. We recently showed that ductal cells clonally expand as self-renewing liver...
7.