Nitin Raj
Overview
Explore the profile of Nitin Raj including associated specialties, affiliations and a list of published articles.
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13
Citations
532
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Recent Articles
1.
Kaiser A, Gatto A, Hanson K, Zhao R, Raj N, Ozawa M, et al.
Nature
. 2023 Jul;
619(7971):851-859.
PMID: 37468633
Lung cancer is the leading cause of cancer deaths worldwide. Mutations in the tumour suppressor gene TP53 occur in 50% of lung adenocarcinomas (LUADs) and are linked to poor prognosis,...
2.
Raj N, Wang M, Seoane J, Zhao R, Kaiser A, Moonie N, et al.
Mol Cell
. 2022 May;
82(13):2370-2384.e10.
PMID: 35512709
The p53 transcription factor drives anti-proliferative gene expression programs in response to diverse stressors, including DNA damage and oncogenic signaling. Here, we seek to uncover new mechanisms through which p53...
3.
Tiu G, Kerr C, Forester C, Krishnarao P, Rosenblatt H, Raj N, et al.
Dev Cell
. 2021 Jul;
56(14):2089-2102.e11.
PMID: 34242585
In ribosomopathies, perturbed expression of ribosome components leads to tissue-specific phenotypes. What accounts for such tissue-selective manifestations as a result of mutations in the ribosome, a ubiquitous cellular machine, has...
4.
Valente L, Tarangelo A, Li A, Naciri M, Raj N, Boutelle A, et al.
J Cell Biol
. 2020 Sep;
219(11).
PMID: 32886745
The mechanisms by which TP53, the most frequently mutated gene in human cancer, suppresses tumorigenesis remain unclear. p53 modulates various cellular processes, such as apoptosis and proliferation, which has led...
5.
Gomez-Ospina N, Scharenberg S, Mostrel N, Bak R, Mantri S, Quadros R, et al.
Nat Commun
. 2019 Sep;
10(1):4045.
PMID: 31492863
Lysosomal enzyme deficiencies comprise a large group of genetic disorders that generally lack effective treatments. A potential treatment approach is to engineer the patient's own hematopoietic system to express high...
6.
Raj N, Bam R
Front Cell Dev Biol
. 2019 Aug;
7:159.
PMID: 31448276
The YAP1/Hippo and p53 pathways are critical protectors of genome integrity in response to DNA damage. Together, these pathways secure cellular adaptation and maintain overall tissue integrity through transcriptional re-programing...
7.
Mello S, Valente L, Raj N, Seoane J, Flowers B, McClendon J, et al.
Cancer Cell
. 2017 Oct;
32(4):460-473.e6.
PMID: 29017057
The p53 transcription factor is a critical barrier to pancreatic cancer progression. To unravel mechanisms of p53-mediated tumor suppression, which have remained elusive, we analyzed pancreatic cancer development in mice...
8.
Mello S, Sinow C, Raj N, Mazur P, Bieging-Rolett K, Broz D, et al.
Genes Dev
. 2017 Jul;
31(11):1095-1108.
PMID: 28698299
The gene is mutated in over half of all cancers, reflecting its critical role as a tumor suppressor. Although p53 is a transcriptional activator that induces myriad target genes, those...
9.
Raj N, Attardi L
Cold Spring Harb Perspect Med
. 2016 Nov;
7(1).
PMID: 27864306
The p53 tumor suppressor is a transcriptional activator, with discrete domains that participate in sequence-specific DNA binding, tetramerization, and transcriptional activation. Mutagenesis and reporter studies have delineated two distinct activation...
10.
Raj N, Attardi L
Curr Biol
. 2013 Jun;
23(12):R527-30.
PMID: 23787049
The p53 tumor suppressor governs multiple cell-intrinsic programs, including cell-cycle arrest and apoptosis, to curb neoplastic growth. A new study reveals that p53 also acts through a novel non-cell-autonomous mechanism,...