Nischalan Pillay
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Explore the profile of Nischalan Pillay including associated specialties, affiliations and a list of published articles.
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60
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2304
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Recent Articles
1.
Mitra S, Farswan A, Piccinelli P, Sydow S, Hesla A, Tsagkozis P, et al.
J Pathol
. 2024 Sep;
264(3):293-304.
PMID: 39258383
Myxofibrosarcoma (MFS) and undifferentiated pleomorphic sarcoma (UPS) are two common and aggressive subtypes of soft tissue sarcoma. The aim of this study was to assess potential transcriptomic differences between MFS...
2.
Abbasi A, Steele C, Bergstrom E, Khandekar A, Farswan A, McKay R, et al.
medRxiv
. 2024 Jul;
PMID: 39040162
Breast and ovarian cancers harboring homologous recombination deficiency (HRD) are sensitive to PARP inhibitors and platinum chemotherapy. Conventionally, detecting HRD involves screening for defects in , , and other relevant...
3.
Kayhanian H, Cross W, van der Horst S, Barmpoutis P, Lakatos E, Caravagna G, et al.
Nat Genet
. 2024 Jul;
56(7):1420-1433.
PMID: 38956208
Mismatch repair (MMR)-deficient cancer evolves through the stepwise erosion of coding homopolymers in target genes. Curiously, the MMR genes MutS homolog 6 (MSH6) and MutS homolog 3 (MSH3) also contain...
4.
Baker T, Lai S, Lynch A, Lesluyes T, Yan H, Ogilvie H, et al.
Cancer Discov
. 2024 Jun;
14(10):1810-1822.
PMID: 38943574
Tumors frequently display high chromosomal instability and contain multiple copies of genomic regions. Here, we describe Gain Route Identification and Timing In Cancer (GRITIC), a generic method for timing genomic...
5.
Haefliger S, Chervova O, Davies C, Loh C, Tirabosco R, Amary F, et al.
Geroscience
. 2024 Jun;
46(5):5203-5209.
PMID: 38879847
Recently, DNA methylation clocks have been proven to be precise age predictors, and the application of these clocks in cancer tissue has revealed a global age acceleration in a majority...
6.
Khandekar A, Vangara R, Barnes M, Diaz-Gay M, Abbasi A, Bergstrom E, et al.
BMC Genomics
. 2023 Aug;
24(1):469.
PMID: 37605126
Background: All cancers harbor somatic mutations in their genomes. In principle, mutations affecting between one and fifty base pairs are generally classified as small mutational events. Conversely, large mutational events...
7.
Haefliger S, Chervova O, Davies C, Nottley S, Hargreaves S, Sumathi V, et al.
J Pathol
. 2023 Jun;
260(4):368-375.
PMID: 37316954
Epithelioid sarcoma is a rare and aggressive mesenchymal tumour, the genetic hallmark of which is the loss of expression of SMARCB1, a key member of the SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin...
8.
Khandekar A, Vangara R, Barnes M, Diaz-Gay M, Abbasi A, Bergstrom E, et al.
bioRxiv
. 2023 Feb;
PMID: 36778452
Background: All cancers harbor somatic mutations in their genomes. In principle, mutations affecting between one and fifty base pairs are generally classified as small mutational events. Conversely, large mutational events...
9.
Cortes-Ciriano I, Steele C, Piculell K, Al-Ibraheemi A, Eulo V, Bui M, et al.
Cancer Discov
. 2023 Jan;
13(3):654-671.
PMID: 36598417
Significance: MPNST is the most common cause of death and morbidity for individuals with NF1, a relatively common tumor predisposition syndrome. Our results suggest that somatic copy-number and methylation profiling...
10.
Islam S, Diaz-Gay M, Wu Y, Barnes M, Vangara R, Bergstrom E, et al.
Cell Genom
. 2022 Nov;
2(11):None.
PMID: 36388765
Mutational signature analysis is commonly performed in cancer genomic studies. Here, we present SigProfilerExtractor, an automated tool for extraction of mutational signatures, and benchmark it against another 13 bioinformatics tools...