Nirav R Patel
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Explore the profile of Nirav R Patel including associated specialties, affiliations and a list of published articles.
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9
Citations
81
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Recent Articles
1.
Patel K, Patel D, Patel N, Kanhed A, Teli D, Gandhi B, et al.
J Biomol Struct Dyn
. 2021 Jul;
40(20):10278-10299.
PMID: 34215173
With the aim to combat a multi-faceted neurodegenerative Alzheimer's disease (AD), a series of carbazole-based semicarbazide and hydrazide derivatives were designed, synthesized and assessed for their cholinesterase (ChE) inhibitory, antioxidant...
2.
Kanhed A, Patel D, Patel N, Sinha A, Thakor P, Patel K, et al.
J Biomol Struct Dyn
. 2020 Oct;
40(6):2498-2515.
PMID: 33111617
To confront a disease like Alzheimer's disease having complex pathogenesis, development of multitarget-directed ligands has emerged as a promising drug discovery approach. In our endeavor towards the development of multitarget-directed...
3.
Patel D, Patel N, Kanhed A, Teli D, Patel K, Gandhi P, et al.
ACS Chem Neurosci
. 2020 Oct;
11(21):3557-3574.
PMID: 33073564
The inadequate clinical efficacy of the present anti-Alzheimer's disease (AD) drugs and their low impact on the progression of Alzheimer's disease in patients have revised the research focus from single...
4.
Kanhed A, Patel D, Teli D, Patel N, Chhabria M, Yadav M
Mol Divers
. 2020 Aug;
25(1):383-401.
PMID: 32737681
The Corona virus Disease (COVID-19) is caused because of novel coronavirus (SARS-CoV-2) pathogen detected in China for the first time, and from there it spread across the globe creating a...
5.
Patel D, Patel N, Kanhed A, Teli D, Patel K, Joshi P, et al.
Bioorg Chem
. 2020 Jun;
101:103977.
PMID: 32485470
Molecules capable of engaging with multiple targets associated with pathological condition of Alzheimer's disease have proved to be potential anti-Alzheimer's agents. In our goal to develop multitarget-directed ligands for the...
6.
Patel D, Patel N, Kanhed A, Patel S, Sinha A, Kansara D, et al.
ACS Chem Neurosci
. 2019 Jul;
10(8):3635-3661.
PMID: 31310717
The multifaceted nature of Alzheimer's disease (AD) demands treatment with multitarget-directed ligands (MTDLs) to confront the key pathological aberrations. A novel series of triazinoindole derivatives were designed and synthesized. In...
7.
Patel N, Patel D, Murumkar P, Yadav M
Eur J Med Chem
. 2016 Jun;
121:671-698.
PMID: 27322757
Thrombosis is a leading cause of death in cardiovascular diseases such as myocardial infarction (MI), unstable angina and acute coronary syndrome (ACS) in the industrialized world. Venous thromboembolism is observed...
8.
Ramachandran S, Arce F, Patel N, Quist A, Cohen D, Lal R
Sci Rep
. 2014 Mar;
4:4424.
PMID: 24651823
Membrane ion channels regulate key cellular functions and their activity is dependent on their 3D structure. Atomic force microscopy (AFM) images 3D structure of membrane channels placed on a solid...
9.
Patel N, Ward M, Beneck D, Cunningham-Rundles S, Moon A
J Obes
. 2010 Aug;
2010.
PMID: 20700412
Background. In adults, it has been shown that obesity is associated with gastroesophageal reflux disease (GERD) and GERD-related complications. There are sparse pediatric data demonstrating associations between childhood overweight and...