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Nino Devidze

Explore the profile of Nino Devidze including associated specialties, affiliations and a list of published articles. Areas
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Articles 33
Citations 3285
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Recent Articles
1.
Davis E, Broestl L, Abdulai-Saiku S, Worden K, Bonham L, Minones-Moyano E, et al.
Sci Transl Med . 2020 Aug; 12(558). PMID: 32848093
A major sex difference in Alzheimer's disease (AD) is that men with the disease die earlier than do women. In aging and preclinical AD, men also show more cognitive deficits....
2.
Min S, Sohn P, Li Y, Devidze N, Johnson J, Krogan N, et al.
J Neurosci . 2018 Mar; 38(15):3680-3688. PMID: 29540553
Hyperacetylation of tau has been implicated in neurodegeneration and cognitive decline in tauopathy brains. The nicotinamide adenosine dinucleotide-dependent class-III protein deacetylase SIRT1 is one of the major enzymes involved in...
3.
Robertson A, Majchrzak M, Smith C, Gagnon R, Devidze N, Banks G, et al.
Neuromuscul Disord . 2017 May; 27(7):635-645. PMID: 28554556
Enzyme-linked and electrochemiluminescence immunoassays were developed for quantification of amino (N-) terminal fragments of the skeletal muscle protein titin (N-ter titin) and qualified for use in detection of urinary N-ter...
4.
Suberbielle E, Djukic B, Evans M, Kim D, Taneja P, Wang X, et al.
Nat Commun . 2015 Dec; 6:8897. PMID: 26615780
Maintaining DNA integrity is vital for all cells and organisms. Defective DNA repair may contribute to neurological disorders, including Alzheimer's disease (AD). We found reduced levels of BRCA1, but not...
5.
Sankaranarayanan S, Barten D, Vana L, Devidze N, Yang L, Cadelina G, et al.
PLoS One . 2015 May; 10(5):e0125614. PMID: 25933020
In Alzheimer's disease (AD), an extensive accumulation of extracellular amyloid plaques and intraneuronal tau tangles, along with neuronal loss, is evident in distinct brain regions. Staging of tau pathology by...
6.
Orr A, Hsiao E, Wang M, Ho K, Kim D, Wang X, et al.
Nat Neurosci . 2015 Jan; 18(3):423-34. PMID: 25622143
Astrocytes express a variety of G protein-coupled receptors and might influence cognitive functions, such as learning and memory. However, the roles of astrocytic Gs-coupled receptors in cognitive function are not...
7.
Cho S, Chen J, Sayed F, Ward M, Gao F, Nguyen T, et al.
J Neurosci . 2015 Jan; 35(2):807-18. PMID: 25589773
Aging is the predominant risk factor for neurodegenerative diseases. One key phenotype as the brain ages is an aberrant innate immune response characterized by proinflammation. However, the molecular mechanisms underlying...
8.
Wes P, Easton A, Corradi J, Barten D, Devidze N, DeCarr L, et al.
PLoS One . 2014 Aug; 9(8):e106050. PMID: 25153994
Filamentous inclusions of the microtubule-associated protein, tau, define a variety of neurodegenerative diseases known as tauopathies, including Alzheimer's disease (AD). To better understand the role of tau-mediated effects on pathophysiology...
9.
Suberbielle E, Sanchez P, Kravitz A, Wang X, Ho K, Eilertson K, et al.
Nat Neurosci . 2013 Mar; 16(5):613-21. PMID: 23525040
We show that a natural behavior, exploration of a novel environment, causes DNA double-strand breaks (DSBs) in neurons of young adult wild-type mice. DSBs occurred in multiple brain regions, were...
10.
Morris M, Hamto P, Adame A, Devidze N, Masliah E, Mucke L
Neurobiol Aging . 2013 Jan; 34(6):1523-9. PMID: 23332171
The microtubule-associated protein tau is expressed throughout the nervous system, most highly in neurons but also in glial cells. Its functions in adult and aging mammals remain to be defined....