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Ningyong Xu

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Articles 15
Citations 202
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Recent Articles
1.
Nguyen A, Battle K, Paudel S, Xu N, Bell J, Ayers L, et al.
J Vis Exp . 2022 Mar; (181). PMID: 35311823
Quantitative assessment of cellular forces and motion advanced considerably over the last four decades. These advancements provided the framework to examine insightful mechanical signaling processes in cell culture systems. However,...
2.
Xu N, Ayers L, Pastukh V, Alexeyev M, Stevens T, Tambe D
PLoS One . 2021 Apr; 16(4):e0250095. PMID: 33891591
Collective migration of endothelial cells is important for wound healing and angiogenesis. During such migration, each constituent endothelial cell coordinates its magnitude and direction of migration with its neighbors while...
3.
Patel N, Nguyen A, Xu N, Ananthasekar S, Alvarez D, Stevens T, et al.
Biochem Biophys Res Commun . 2019 Dec; 522(2):279-285. PMID: 31879014
In the field of endothelial biology, the term "shear forces" is tied to the forces exerted by the flowing blood on the quiescent cells. But endothelial cells themselves also exert...
4.
Patel G, Xu N, Nguyen A, Alvarez D, Fredberg J, Stevens T, et al.
Biochem Biophys Res Commun . 2019 Sep; 519(2):337-343. PMID: 31514994
The mechanical microenvironment of an endothelial cell includes a stable protein scaffold on the basal side, flowing blood on the apical side and contractile cells on the lateral sides. Interaction...
5.
Zhou C, Francis C, Xu N, Stevens T
Pulm Circ . 2018 Aug; 8(4):2045894018798569. PMID: 30124139
The canonical transient receptor potential 4 (TRPC4) protein contributes to the molecular make-up of endothelial store-operated calcium entry channels. Store-operated calcium entry is a prominent mode of calcium influx in...
6.
Francis M, Xu N, Zhou C, Stevens T
Am J Pathol . 2016 Apr; 186(6):1701-9. PMID: 27083517
The canonical transient receptor potential channel 4 (TRPC4) comprises an endothelial store-operated Ca(2+) entry channel, and TRPC4 inactivation confers a survival benefit in pulmonary arterial hypertension (PAH). Endothelial Ca(2+) signals...
7.
Xu N, Cioffi D, Alexeyev M, Rich T, Stevens T
Am J Physiol Cell Physiol . 2014 Nov; 308(4):C277-88. PMID: 25428882
Orai1 interacts with transient receptor potential protein of the canonical subfamily (TRPC4) and contributes to calcium selectivity of the endothelial cell store-operated calcium entry current (ISOC). Orai1 silencing increases sodium...
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Obiako B, Calchary W, Xu N, Kunstadt R, Richardson B, Nix J, et al.
Am J Physiol Lung Cell Mol Physiol . 2013 May; 305(2):L185-92. PMID: 23686854
It is becoming increasingly apparent that cAMP signals within the pulmonary endothelium are highly compartmentalized, and this compartmentalization is critical to maintaining endothelial barrier integrity. Studies demonstrate that the exogenous...
10.
Xu N, Engbers J, Khaja S, Xu L, Clark J, Hansen M
Hear Res . 2011 Dec; 283(1-2):33-44. PMID: 22154930
Regrowth of peripheral spiral ganglion neuron (SGN) fibers is a primary objective in efforts to improve cochlear implant outcomes and to potentially reinnervate regenerated hair cells. Cyclic adenosine monophosphate (cAMP)...