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Nina Himmerkus

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Articles 62
Citations 2209
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Demirci H, Bahena-Lopez J, Smorodchenko A, Su X, Nelson J, Yang C, et al.
bioRxiv . 2025 Feb; PMID: 39896580
Kidney thick ascending limb cells reabsorb sodium, potassium, calcium, and magnesium and contribute to urinary concentration. These cells are typically viewed as of a single type that recycles potassium across...
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Himmerkus N, Quintanova C, Bhullar H, van Megen W, Deluque A, Skjodt K, et al.
J Am Soc Nephrol . 2025 Jan; PMID: 39836479
No abstract available.
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Bazua-Valenti S, Brown M, Zavras J, Riedl Khursigara M, Grinkevich E, Sidhom E, et al.
J Clin Invest . 2024 Dec; 134(24). PMID: 39680459
The trafficking dynamics of uromodulin (UMOD), the most abundant protein in human urine, play a critical role in the pathogenesis of kidney disease. Monoallelic mutations in the UMOD gene cause...
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Jonusaite S, Himmerkus N
Comp Biochem Physiol A Mol Integr Physiol . 2024 Sep; 298:111741. PMID: 39276851
Regulation of salt and water balance occupies a dominant role in the physiology of many animals and often relies on the function of the renal system. In the mammalian kidney,...
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Radvanyi Z, Schnitzbauer U, Pastor-Arroyo E, Holker S, Himmerkus N, Bleich M, et al.
Pflugers Arch . 2024 Aug; 476(10):1597-1612. PMID: 39115555
Intestinal absorption of phosphate is bimodal, consisting of a transcellular pathway and a poorly characterized paracellular mode, even though the latter one contributes to the bulk of absorption under normal...
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Kriuchkova N, Breiderhoff T, Muller D, Yilmaz D, Demirci H, Drewell H, et al.
Acta Physiol (Oxf) . 2023 Jan; 237(3):e13927. PMID: 36606514
Aim: Perturbed calcium homeostasis limits life expectancy in familial hypomagnesaemia with hypercalciuria and nephrocalcinosis (FHHNC). This rare disease occurs by loss-of-function mutations in CLDN16 or CLDN19 genes, causing impaired paracellular...
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Hinze C, Kocks C, Leiz J, Karaiskos N, Boltengagen A, Cao S, et al.
Genome Med . 2022 Sep; 14(1):103. PMID: 36085050
Background: Acute kidney injury (AKI) occurs frequently in critically ill patients and is associated with adverse outcomes. Cellular mechanisms underlying AKI and kidney cell responses to injury remain incompletely understood....
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Gonschior H, Schmied C, Van der Veen R, Eichhorst J, Himmerkus N, Piontek J, et al.
Nat Commun . 2022 Aug; 13(1):4985. PMID: 36008380
The paracellular passage of ions and small molecules across epithelia is controlled by tight junctions, complex meshworks of claudin polymers that form tight seals between neighboring cells. How the nanoscale...
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Quintanova C, Himmerkus N, Svendsen S, von Schwerdtner O, Merkel C, Pinckert L, et al.
Ann N Y Acad Sci . 2022 Aug; 1517(1):266-278. PMID: 35996827
Claudin-10b is an important component of the tight junction in the thick ascending limb (TAL) of Henle's loop and allows paracellular sodium transport. In immunofluorescence stainings, claudin-10b-positive cells exhibited extensive...