Nilaksh Gupta
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Explore the profile of Nilaksh Gupta including associated specialties, affiliations and a list of published articles.
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11
Citations
1606
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Recent Articles
1.
Lee J, Yoon H, Ko Y, Kim E, Song S, Hue S, et al.
ACS Nano
. 2024 Aug;
18(33):22298-22315.
PMID: 39117621
A series of successes in RNA interference (RNAi) therapies for liver diseases using lipid nanoparticles and -acetylgalactosamine have heralded a current era of RNA therapeutics. However, alternative delivery strategies are...
2.
Witkowski M, Nemet I, Li X, Wilcox J, Ferrell M, Alamri H, et al.
Eur Heart J
. 2024 Jun;
45(27):2439-2452.
PMID: 38842092
Background And Aims: The pathways and metabolites that contribute to residual cardiovascular disease risks are unclear. Low-calorie sweeteners are widely used sugar substitutes in processed foods with presumed health benefits....
3.
Witkowski M, Nemet I, Alamri H, Wilcox J, Gupta N, Nimer N, et al.
Nat Med
. 2023 Feb;
29(3):710-718.
PMID: 36849732
Artificial sweeteners are widely used sugar substitutes, but little is known about their long-term effects on cardiometabolic disease risks. Here we examined the commonly used sugar substitute erythritol and atherothrombotic...
4.
Kim S, Bale S, Verma P, Wan Q, Ma F, Gudjonsson J, et al.
iScience
. 2022 Jul;
25(7):104669.
PMID: 35856022
Intestinal dysbiosis is prominent in systemic sclerosis (SSc), but it remains unknown how it contributes to microvascular injury and fibrosis that are hallmarks of this disease. Trimethylamine (TMA) is generated...
5.
Organ C, Li Z, Sharp 3rd T, Polhemus D, Gupta N, Goodchild T, et al.
J Am Heart Assoc
. 2020 May;
9(10):e016223.
PMID: 32390485
Background Patients at increased risk for coronary artery disease and adverse prognosis during heart failure exhibit increased levels of circulating trimethylamine N-oxide (TMAO), a metabolite formed in the metabolism of...
6.
Gupta N, Buffa J, Roberts A, Sangwan N, Skye S, Li L, et al.
Arterioscler Thromb Vasc Biol
. 2020 Mar;
40(5):1239-1255.
PMID: 32212854
Objective: Gut microbial metabolism of dietary choline, a nutrient abundant in a Western diet, produces trimethylamine (TMA) and the atherothrombosis- and fibrosis-promoting metabolite TMA-N-oxide (TMAO). Recent clinical and animal studies...
7.
Nemet I, Saha P, Gupta N, Zhu W, Romano K, Skye S, et al.
Cell
. 2020 Mar;
180(5):862-877.e22.
PMID: 32142679
Using untargeted metabolomics (n = 1,162 subjects), the plasma metabolite (m/z = 265.1188) phenylacetylglutamine (PAGln) was discovered and then shown in an independent cohort (n = 4,000 subjects) to be...
8.
Roberts A, Gu X, Buffa J, Hurd A, Wang Z, Zhu W, et al.
Nat Med
. 2018 Aug;
24(9):1407-1417.
PMID: 30082863
Trimethylamine N-oxide (TMAO) is a gut microbiota-derived metabolite that enhances both platelet responsiveness and in vivo thrombosis potential in animal models, and TMAO plasma levels predict incident atherothrombotic event risks...
9.
Zhu W, Gregory J, Org E, Buffa J, Gupta N, Wang Z, et al.
Cell
. 2016 Mar;
165(1):111-124.
PMID: 26972052
Normal platelet function is critical to blood hemostasis and maintenance of a closed circulatory system. Heightened platelet reactivity, however, is associated with cardiometabolic diseases and enhanced potential for thrombotic events....
10.
Gupta N, Li W, McIntyre T
Arterioscler Thromb Vasc Biol
. 2015 Oct;
35(12):2657-66.
PMID: 26471267
Objective: Platelets express a functional ubiquitin-proteasome system. Mass spectrometry shows that platelets contain several deubiquitinases, but whether these are functional, modulate the proteome, or affect platelet reactivity are unknown. Approach...