Nikolai Slavov
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Explore the profile of Nikolai Slavov including associated specialties, affiliations and a list of published articles.
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72
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Recent Articles
1.
Liu Y, He S, Pyo A, Zheng S, Chen M, Cheloufi S, et al.
bioRxiv
. 2025 Mar;
PMID: 40027791
Ribonuclease (RNase) MRP is a conserved RNA-based enzyme that is essential for maturation of ribosomal RNA (rRNA) in eukaryotes. However, the composition and RNA substrate specificity of this multisubunit ribonucleoprotein...
2.
Leduc A, Slavov N
bioRxiv
. 2025 Feb;
PMID: 39990504
Cellular protein concentrations are maintained through a balance of synthesis and clearance. Clearance occurs through both protein degradation and growth-dependent dilution. At slow growth, clearance is dominated by degradation, which...
3.
Rengarajan S, Derks J, Bellott D, Slavov N, Page D
Genome Res
. 2025 Jan;
35(1):20-30.
PMID: 39794123
The Y-linked gene and its X-linked homolog survived the evolution of the human sex chromosomes from ordinary autosomes. encodes a multifunctional RNA helicase, with mutations causing developmental disorders and cancers....
4.
Khan S, Elcheikhali M, Leduc A, Huffman R, Derks J, Franks A, et al.
bioRxiv
. 2024 Oct;
PMID: 39416047
Single-cell tissue atlases commonly use RNA abundances as surrogates for protein abundances. Yet, protein abundance also depends on the regulation of protein synthesis and degradation rates. To estimate the contributions...
5.
Iwamoto-Stohl L, Petelski A, Meglicki M, Fu A, Khan S, Specht H, et al.
bioRxiv
. 2024 Sep;
PMID: 39253500
Pre-patterning of the embryo, driven by spatially localized factors, is a common feature across several non-mammalian species . However, mammals display regulative development and thus it was thought that blastomeres...
6.
Tsour S, Machne R, Leduc A, Widmer S, Guez J, Karczewski K, et al.
bioRxiv
. 2024 Sep;
PMID: 39253435
Amino acid substitutions may substantially alter protein stability and function, but the contribution of substitutions arising from alternate translation (deviations from the genetic code) is unknown. To explore it, we...
7.
Leduc A, Khoury L, Cantlon J, Khan S, Slavov N
Nat Protoc
. 2024 Aug;
19(12):3750-3776.
PMID: 39117766
Single-cell proteomics by mass spectrometry (MS) allows the quantification of proteins with high specificity and sensitivity. To increase its throughput, we developed nano-proteomic sample preparation (nPOP), a method for parallel...
8.
Leduc A, Xu Y, Shipkovenska G, Dou Z, Slavov N
bioRxiv
. 2024 Aug;
PMID: 39091738
Limiting artifacts during sample preparation can significantly increase data quality in single-cell proteomics experiments. Towards this goal, we characterize the impact of protein leakage by analyzing thousands of primary single...
9.
Rengarajan S, Derks J, Bellott D, Slavov N, Page D
bioRxiv
. 2024 Jul;
PMID: 39026797
The Y-linked gene and its X-linked homolog survived the evolution of the human sex chromosomes from ordinary autosomes. encodes a multi-functional RNA helicase, with mutations causing developmental disorders and cancers....
10.
Derks J, Jonson T, Leduc A, Khan S, Khoury L, Rafiee M, et al.
bioRxiv
. 2024 Jul;
PMID: 38948785
The physiological response of a cell to stimulation depends on its proteome configuration. Therefore, the abundance variation of regulatory proteins across unstimulated single cells can be associatively linked with their...