Andrew Leduc
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Explore the profile of Andrew Leduc including associated specialties, affiliations and a list of published articles.
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15
Citations
338
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Recent Articles
1.
Leduc A, Slavov N
bioRxiv
. 2025 Feb;
PMID: 39990504
Cellular protein concentrations are maintained through a balance of synthesis and clearance. Clearance occurs through both protein degradation and growth-dependent dilution. At slow growth, clearance is dominated by degradation, which...
2.
Khan S, Elcheikhali M, Leduc A, Huffman R, Derks J, Franks A, et al.
bioRxiv
. 2024 Oct;
PMID: 39416047
Single-cell tissue atlases commonly use RNA abundances as surrogates for protein abundances. Yet, protein abundance also depends on the regulation of protein synthesis and degradation rates. To estimate the contributions...
3.
Tsour S, Machne R, Leduc A, Widmer S, Guez J, Karczewski K, et al.
bioRxiv
. 2024 Sep;
PMID: 39253435
Amino acid substitutions may substantially alter protein stability and function, but the contribution of substitutions arising from alternate translation (deviations from the genetic code) is unknown. To explore it, we...
4.
Leduc A, Khoury L, Cantlon J, Khan S, Slavov N
Nat Protoc
. 2024 Aug;
19(12):3750-3776.
PMID: 39117766
Single-cell proteomics by mass spectrometry (MS) allows the quantification of proteins with high specificity and sensitivity. To increase its throughput, we developed nano-proteomic sample preparation (nPOP), a method for parallel...
5.
Leduc A, Xu Y, Shipkovenska G, Dou Z, Slavov N
bioRxiv
. 2024 Aug;
PMID: 39091738
Limiting artifacts during sample preparation can significantly increase data quality in single-cell proteomics experiments. Towards this goal, we characterize the impact of protein leakage by analyzing thousands of primary single...
6.
Derks J, Jonson T, Leduc A, Khan S, Khoury L, Rafiee M, et al.
bioRxiv
. 2024 Jul;
PMID: 38948785
The physiological response of a cell to stimulation depends on its proteome configuration. Therefore, the abundance variation of regulatory proteins across unstimulated single cells can be associatively linked with their...
7.
Leduc A, Koury L, Cantlon J, Slavov N
bioRxiv
. 2023 Dec;
PMID: 38076795
Single-cell proteomics by mass spectrometry (MS) allows quantifying proteins with high specificity and sensitivity. To increase its throughput, we developed nPOP, a method for parallel preparation of thousands of single...
8.
Wallmann G, Leduc A, Slavov N
J Proteome Res
. 2023 Sep;
22(10):3149-3158.
PMID: 37695820
Mass spectrometry (MS) enables specific and accurate quantification of proteins with ever-increasing throughput and sensitivity. Maximizing this potential of MS requires optimizing data acquisition parameters and performing efficient quality control...
9.
Leduc A, Harens H, Slavov N
ArXiv
. 2023 Aug;
PMID: 37645043
Biological functions stem from coordinated interactions among proteins, nucleic acids and small molecules. Mass spectrometry technologies for reliable, high throughput single-cell proteomics will add a new modality to genomics and...
10.
Montalvo A, Gruskin Z, Leduc A, Liu M, Gao Z, Ahn J, et al.
bioRxiv
. 2023 Aug;
PMID: 37609178
How ubiquitous circadian clocks orchestrate tissue-specific outputs is not well understood. Pancreatic β cell-autonomous clocks attune insulin secretion to daily energy cycles, and desynchrony from genetic or behavioral disruptions raises...