Nigel Rust
Overview
Explore the profile of Nigel Rust including associated specialties, affiliations and a list of published articles.
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10
Citations
842
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Recent Articles
1.
Howles S, Hannan F, Babinsky V, Rogers A, Gorvin C, Rust N, et al.
N Engl J Med
. 2016 Apr;
374(14):1396-1398.
PMID: 27050234
No abstract available.
2.
Babinsky V, Hannan F, Gorvin C, Howles S, Nesbit M, Rust N, et al.
J Biol Chem
. 2016 Mar;
291(20):10876-85.
PMID: 26994139
Germline loss- and gain-of-function mutations of G-protein α-11 (Gα11), which couples the calcium-sensing receptor (CaSR) to intracellular calcium (Ca(2+) i) signaling, lead to familial hypocalciuric hypercalcemia type 2 (FHH2) and...
3.
Piret S, Gorvin C, Pagnamenta A, Howles S, Cranston T, Rust N, et al.
J Bone Miner Res
. 2016 Jan;
31(6):1207-14.
PMID: 26818911
Autosomal dominant hypocalcemia (ADH) is characterized by hypocalcemia, inappropriately low serum parathyroid hormone concentrations and hypercalciuria. ADH is genetically heterogeneous with ADH type 1 (ADH1), the predominant form, being caused...
4.
Gorvin C, Cranston T, Hannan F, Rust N, Qureshi A, Nesbit M, et al.
J Bone Miner Res
. 2016 Jan;
31(6):1200-6.
PMID: 26729423
Familial hypocalciuric hypercalcemia (FHH) is a genetically heterogeneous disorder with three variants, FHH1 to FHH3. FHH1 is caused by loss-of-function mutations of the calcium-sensing receptor (CaSR), a G-protein coupled receptor...
5.
Nesbit M, Hannan F, Howles S, Babinsky V, Head R, Cranston T, et al.
N Engl J Med
. 2013 Jun;
368(26):2476-2486.
PMID: 23802516
Background: Familial hypocalciuric hypercalcemia is a genetically heterogeneous disorder with three variants: types 1, 2, and 3. Type 1 is due to loss-of-function mutations of the calcium-sensing receptor, a guanine...
6.
Nesbit M, Hannan F, Howles S, Reed A, Cranston T, Thakker C, et al.
Nat Genet
. 2012 Dec;
45(1):93-7.
PMID: 23222959
Adaptor protein-2 (AP2), a central component of clathrin-coated vesicles (CCVs), is pivotal in clathrin-mediated endocytosis, which internalizes plasma membrane constituents such as G protein-coupled receptors (GPCRs). AP2, a heterotetramer of...
7.
Haenni S, Ji Z, Hoque M, Rust N, Sharpe H, Eberhard R, et al.
Nucleic Acids Res
. 2012 Apr;
40(13):6304-18.
PMID: 22467213
Despite the many advantages of Caenorhabditis elegans, biochemical approaches to study tissue-specific gene expression in post-embryonic stages are challenging. Here, we report a novel experimental approach for efficient determination of...
8.
Hannan F, Nesbit M, Zhang C, Cranston T, Curley A, Harding B, et al.
Hum Mol Genet
. 2012 Mar;
21(12):2768-78.
PMID: 22422767
The calcium-sensing receptor (CaSR) is a G-protein-coupled receptor that has an extracellular bilobed venus flytrap domain (VFTD) predicted to contain five calcium (Ca(2+))-binding sites. To elucidate the structure-function relationships of...
9.
Geremia A, Arancibia-Carcamo C, Fleming M, Rust N, Singh B, Mortensen N, et al.
J Exp Med
. 2011 May;
208(6):1127-33.
PMID: 21576383
Results of experimental and genetic studies have highlighted the role of the IL-23/IL-17 axis in the pathogenesis of inflammatory bowel disease (IBD). IL-23-driven inflammation has been primarily linked to Th17...
10.
Ferry H, Crockford T, Cockford T, Silver K, Rust N, Goodnow C, et al.
Eur J Immunol
. 2005 Nov;
35(12):3655-63.
PMID: 16278813
B cell fate is determined by the strength of signals from the antigen receptor and from co-receptors that adjust the activation threshold and tune the B cell to its environment....